FSHB抗体,Mouse Monoclonal FSHB Antibody
  • FSHB抗体,Mouse Monoclonal FSHB Antibody
  • FSHB抗体,Mouse Monoclonal FSHB Antibody
  • FSHB抗体,Mouse Monoclonal FSHB Antibody

FSHB抗体 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:FSHB抗体英文名称:Mouse Monoclonal FSHB Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 658 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: FSHB
2025-05-10 FSHB抗体 Mouse Monoclonal FSHB Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 658 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

Entrez GeneID2488
clone3C1E4
WB Predicted band size14.7kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human FSHB (AA: 19-129) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using FSHB mouse mAb against Cos7 (1), HepG2 (2), HEK293 (3) cell lysate.    


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       Flow cytometric analysis of HepG2 cells using FSHB mouse mAb (green) and negative control (red).    


           

参考文献

以下是关于FSHB抗体的假设性参考文献示例,供参考:

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1. **标题**: *"Development of a High-Specificity Monoclonal Antibody for FSHB and Its Application in Reproductive Health Diagnostics"*

**作者**: Smith, J. et al. (2015)

**摘要**: 该研究报道了一种针对FSHB亚基的单克隆抗体的开发,验证了其在ELISA和免疫组化中的高灵敏度和特异性,并成功应用于检测血清FSH水平,为多囊卵巢综合征等生殖疾病的诊断提供了新工具。

2. **标题**: *"Neutralizing FSHB Antibodies Impair Ovarian Follicle Development in a Mouse Model"*

**作者**: Jones, R. et al. (2018)

**摘要**: 通过向小鼠注射抗FSHB中和抗体,研究发现其可显著降低FSH活性,导致卵泡发育停滞和雌激素水平下降,提示FSHB抗体在生殖调控中的潜在治疗或避孕应用。

3. **标题**: *"Autoantibodies Against FSHB in Idiopathic Hypogonadism: A Novel Biomarker for Infertility"*

**作者**: Lee, S. et al. (2020)

**摘要**: 研究在部分不明原因性腺功能减退患者血清中检测到抗FSHB自身抗体,这些抗体可能通过干扰FSH信号传导导致生殖功能障碍,为不孕症的免疫机制提供了新见解。

4. **标题**: *"FSHB Gene Mutations and Antibody Cross-Reactivity in Hormone Deficiency Syndromes"*

**作者**: Chen, M. et al. (2019)

**摘要**: 分析FSHB基因突变患者的血清样本,发现部分突变可能诱导针对FSHB的自身抗体产生,导致获得性FSH缺乏,揭示了遗传与免疫因素的交互作用。

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**注**:以上文献为示例性质,实际研究中可能需要通过学术数据库(如PubMed、Web of Science)以关键词“FSHB antibody”“anti-FSHB”等检索具体文献。

       

背景信息

Follicle-stimulating hormone (FSH) is a glycoprotein critical for reproductive function, regulating gametogenesis and steroidogenesis. It comprises two subunits: α (common to gonadotropins) and β (FSHB), which confers biological specificity. FSHB antibodies target the β-subunit, disrupting FSH signaling. These antibodies are primarily studied in two contexts: research tools and clinical pathology.

In research, FSHB antibodies enable precise detection of FSH in immunoassays or tissue studies, aiding investigations into reproductive disorders, pituitary function, and hormone dynamics. They also help map FSH receptor interactions or hormone biosynthesis pathways. Clinically, autoantibodies against FSHB are rare but implicated in autoimmune hypophysitis or infertility, where they neutralize FSH bioactivity, impairing folliculogenesis in females or spermatogenesis in males. Such cases highlight FSHB's role in reproductive health and the pathological consequences of its dysregulation.

Additionally, FSHB antibodies are explored in contraceptive vaccine development, leveraging immunoneutralization to suppress fertility transiently. However, challenges include ensuring specificity and avoiding cross-reactivity with other glycoprotein hormones (e.g., TSH, LH) due to shared α-subunits. Advances in monoclonal antibody technology have improved target selectivity, enhancing both diagnostic accuracy and therapeutic potential. Overall, FSHB antibodies serve as vital tools for unraveling reproductive biology and addressing associated disorders.

       
关键字: FSHB抗体;FSHB;FSHB Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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