MAPK7抗体,Mouse Monoclonal MAPK7 Antibody
  • MAPK7抗体,Mouse Monoclonal MAPK7 Antibody
  • MAPK7抗体,Mouse Monoclonal MAPK7 Antibody
  • MAPK7抗体,Mouse Monoclonal MAPK7 Antibody

MAPK7抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:MAPK7抗体英文名称:Mouse Monoclonal MAPK7 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 668 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: MAPK7
2025-05-10 MAPK7抗体 Mouse Monoclonal MAPK7 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 668 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesBMK1; ERK4; ERK5; PRKM7
Entrez GeneID5598
clone8H1D5
WB Predicted band size88.4kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human MAPK7 (AA: 411-556) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using MAPK7 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using MAPK7 mouse mAb with DAB staining.    


           

参考文献

以下是关于MAPK7(ERK5)抗体的3篇参考文献示例(文献名称、作者及摘要概括):

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1. **文献名称**:*"ERK5/MAPK7 promotes tumorigenesis in triple-negative breast cancer via vascular mimicry"*

**作者**:Sawano et al. (2018)

**摘要**:研究利用MAPK7特异性抗体进行Western blot和免疫组化,发现ERK5在乳腺癌中通过调控血管生成拟态促进肿瘤侵袭,提示其作为潜在治疗靶点。

2. **文献名称**:*"ERK5 regulates endothelial cell apoptosis in atherosclerosis via NF-κB signaling"*

**作者**:Zheng et al. (2019)

**摘要**:通过MAPK7抗体敲低实验,证明ERK5通过抑制NF-κB通路保护内皮细胞凋亡,为动脉粥样硬化机制提供新见解。

3. **文献名称**:*"MAPK7 antibody-based detection reveals its role in inflammatory bowel disease pathogenesis"*

**作者**:Chen et al. (2020)

**摘要**:利用抗MAPK7抗体进行组织染色和流式分析,揭示ERK5在肠道炎症中通过调控巨噬细胞极化加剧疾病进展。

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*注:以上为示例文献,实际引用需核对真实论文信息。建议通过PubMed或Google Scholar搜索关键词“MAPK7 antibody”“ERK5”获取具体文献。*

       

背景信息

The mitogen-activated protein kinase 7 (MAPK7), also known as extracellular signal-regulated kinase 5 (ERK5), is a member of the MAPK family involved in critical cellular processes such as proliferation, differentiation, and survival. Unlike other MAPKs, MAPK7 contains a unique C-terminal tail that regulates its activation and nuclear translocation. It is primarily activated by dual phosphorylation of threonine and tyrosine residues in the T-E-Y motif by upstream kinases like MEK5. MAPK7 plays a key role in stress responses, angiogenesis, and developmental pathways, with dysregulation linked to cancer, cardiovascular diseases, and neurodegenerative disorders.

MAPK7 antibodies are essential tools for detecting and studying the expression, localization, and activation status of MAPK7 in various biological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate MAPK7 signaling dynamics. Phospho-specific MAPK7 antibodies targeting the phosphorylated T-E-Y motif are particularly valuable for assessing its activation state. Research applications include exploring MAPK7's role in tumor progression, where its overexpression in certain cancers correlates with poor prognosis, or in cardiovascular studies examining its impact on endothelial cell function. Validating antibody specificity using knockout/knockdown controls is critical to ensure reliable experimental outcomes, as cross-reactivity with other MAPKs can occur. Overall, MAPK7 antibodies are pivotal for unraveling the protein's diverse physiological and pathological functions.

       
关键字: MAPK7抗体;MAPK7;MAPK7 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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