TUBE1抗体,Mouse Monoclonal TUBE1 Antibody
  • TUBE1抗体,Mouse Monoclonal TUBE1 Antibody
  • TUBE1抗体,Mouse Monoclonal TUBE1 Antibody
  • TUBE1抗体,Mouse Monoclonal TUBE1 Antibody

TUBE1抗体 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:TUBE1抗体英文名称:Mouse Monoclonal TUBE1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 676 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: TUBE1
2025-05-10 TUBE1抗体 Mouse Monoclonal TUBE1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 676 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesTUBE; dJ142L7.2
Entrez GeneID51175
clone5F3B7
WB Predicted band size53kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human TUBE1 (AA: 314-472) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Flow cytometric analysis of Hela cells using TUBE1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using TUBE1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using TUBE1 mouse mAb with DAB staining.    


           

参考文献

以下是关于TUBE1抗体的3篇代表性文献示例(注:以下内容为模拟虚构,实际文献需通过数据库检索验证):

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1. **文献名称**:*TUBE1 regulates ciliary microtubule assembly through interaction with CEP97*

**作者**:Antonio Valencia et al.

**摘要**:研究揭示了TUBE1蛋白在纤毛微管结构组装中的关键作用,发现其通过结合CEP97调控微管稳定性,并开发了特异性TUBE1抗体用于定位分析。

2. **文献名称**:*TUBE1 functions as a substrate-specific adaptor for E3 ubiquitin ligase in neuronal development*

**作者**:Rachel Giles et al.

**摘要**:该文献利用TUBE1抗体进行免疫共沉淀实验,证明TUBE1作为E3泛素连接酶适配体,调控神经元轴突发育相关蛋白的泛素化降解。

3. **文献名称**:*TUBE1 mutations and antibody-based detection in Joubert syndrome*

**作者**:Emily Chen et al.

**摘要**:通过患者样本分析,发现TUBE1基因突变与Joubert综合征相关,建立的TUBE1抗体免疫组化方法可用于临床病理诊断。

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如需真实文献,建议通过PubMed或Google Scholar搜索“TUBE1 antibody”或“TUBE1 function”获取最新研究。

       

背景信息

TUBE1 antibody targets tubulin beta-1 (TUBB1), a member of the tubulin superfamily critical for microtubule formation. Microtubules are dynamic cytoskeletal structures involved in cell division, intracellular transport, and maintaining cell shape. The TUBB1 gene encodes β-tubulin, which pairs with α-tubulin to form heterodimers—the building blocks of microtubules. β-tubulin isoforms, including TUBB1. exhibit tissue-specific expression and functional diversity, with TUBB1 particularly noted for its role in megakaryocytes and platelets.

TUBE1 antibodies are widely used in research to study microtubule dynamics, cell cycle regulation, and cellular responses to microtubule-targeting drugs (e.g., taxanes, vinca alkaloids). They are applied in techniques like Western blot (WB), immunofluorescence (IF), and immunohistochemistry (IHC) to detect β-tubulin expression, localization, and post-translational modifications (e.g., tyrosination, acetylation) linked to microtubule stability and function.

Aberrant β-tubulin expression or mutations are associated with diseases such as cancer (chemoresistance), neurodevelopmental disorders, and platelet disorders. TUBE1 antibodies also serve as loading controls in protein analysis due to β-tubulin’s constitutive expression. However, researchers must verify antibody specificity, as cross-reactivity with other β-tubulin isoforms (e.g., TUBB, TUBB3) can occur. Recent studies emphasize its utility in exploring microtubule-related mechanisms in neurodegeneration, cilia function, and mitotic defects, underscoring its importance in basic and translational research.

       
关键字: TUBE1抗体;TUBE1;TUBE1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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