PPARGC1B (peroxisome proliferator-activated receptor gamma coactivator 1-beta), also known as PGC-1β, is a transcriptional coactivator involved in regulating mitochondrial biogenesis, oxidative metabolism, and energy homeostasis. It shares structural and functional similarities with PPARGC1A (PGC-1α) and interacts with nuclear receptors, transcription factors (e.g., PPARs, ERRα), and other regulators to modulate gene expression in response to metabolic demands. PPARGC1B is highly expressed in tissues with elevated energy requirements, such as skeletal muscle, heart, liver, and brown adipose tissue, playing roles in adaptive thermogenesis, fatty acid oxidation, and glucose metabolism.
The PPARGC1B antibody is a critical tool for detecting and quantifying PPARGC1B protein expression in research. It is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study its tissue distribution, subcellular localization, and dynamic regulation under physiological or pathological conditions. Dysregulation of PPARGC1B has been implicated in metabolic disorders (e.g., obesity, type 2 diabetes), cardiovascular diseases, neurodegenerative conditions, and cancer, making this antibody valuable for exploring disease mechanisms and therapeutic targets. Studies also highlight its role in mitochondrial dysfunction, aging, and exercise adaptation. Validated antibodies ensure specificity for PPARGC1B, distinguishing it from PGC-1α, and are often tested in knockout models or siRNA-treated samples to confirm reliability.