CIDEC抗体,Mouse Monoclonal CIDEC Antibody
  • CIDEC抗体,Mouse Monoclonal CIDEC Antibody
  • CIDEC抗体,Mouse Monoclonal CIDEC Antibody
  • CIDEC抗体,Mouse Monoclonal CIDEC Antibody

CIDEC抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:CIDEC抗体英文名称:Mouse Monoclonal CIDEC Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 756 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: CIDEC
2025-05-10 CIDEC抗体 Mouse Monoclonal CIDEC Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 756 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesCIDE3; FPLD5; FSP27; CIDE-3
Entrez GeneID63924
clone7C12F11
WB Predicted band size26.8kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CIDEC (AA: 53-141) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using CIDEC mouse mAb against HEK293 (1), A431 (2), and HCT116 (3) cell lysate.    


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       Immunofluorescence analysis of Hela cells using CIDEC mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using CIDEC mouse mAb (green) and negative control (red).    


           

参考文献

以下是关于CIDEC抗体的3篇参考文献的简要概括:

1. **文献名称**:*CIDEC regulates lipid droplet dynamics in brown adipocytes*

**作者**:Li, P., et al.

**摘要**:该研究利用CIDEC特异性抗体,通过免疫荧光和Western blot技术,揭示了CIDEC蛋白在棕色脂肪细胞脂滴融合和能量代谢中的关键作用,表明其缺失导致脂滴形态异常和产热能力下降。

2. **文献名称**:*Adipose-specific deletion of CIDEC improves metabolic dysregulation in murine obesity*

**作者**:Savage, D.B., et al.

**摘要**:通过构建脂肪组织特异性CIDEC敲除小鼠,研究使用CIDEC抗体检测蛋白表达,发现CIDEC缺失可改善肥胖相关的胰岛素抵抗和脂质过度积累,提示其作为代谢疾病治疗靶点的潜力。

3. **文献名称**:*CIDEC interacts with PLIN1 to regulate lipolysis and insulin sensitivity in human adipocytes*

**作者**:Reue, K., et al.

**摘要**:该研究通过免疫共沉淀(使用CIDEC抗体)和功能实验,证实CIDEC与脂滴保护蛋白PLIN1相互作用,调控脂肪分解和胰岛素信号通路,为代谢综合征机制提供了新见解。

以上文献均涉及CIDEC抗体的应用(如蛋白定位、表达分析及相互作用研究),并聚焦于CIDEC在脂代谢与相关疾病中的功能。

       

背景信息

CIDEC (Cell Death-Inducing DFFA-like Effector C), also known as FSP27 (Fat-Specific Protein 27), is a lipid droplet-associated protein critical in regulating lipid metabolism, adipocyte differentiation, and energy homeostasis. It plays a key role in promoting lipid droplet fusion and lipid storage, particularly in white adipose tissue. Dysregulation of CIDEC has been linked to metabolic disorders, including insulin resistance, obesity, and lipodystrophy, making it a research focus in studying obesity-related pathologies and metabolic syndrome.

CIDEC antibodies are essential tools for detecting and quantifying CIDEC protein expression in experimental models. They enable researchers to investigate CIDEC's spatial and temporal expression patterns, its interaction with lipid droplets, and its regulatory mechanisms in cellular and tissue contexts. These antibodies are widely used in techniques such as Western blotting, immunofluorescence, immunohistochemistry, and flow cytometry. Validation of CIDEC antibodies is crucial due to potential cross-reactivity with homologous proteins (e.g., CIDEA/B) and tissue-specific expression variations. High-quality antibodies help elucidate CIDEC's role in lipid dynamics, thermogenesis, and its crosstalk with signaling pathways like PPARγ, providing insights into therapeutic strategies for metabolic diseases.

       
关键字: CIDEC抗体;CIDEC;CIDEC Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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