FOXP3抗体,Mouse Monoclonal FOXP3 Antibody
  • FOXP3抗体,Mouse Monoclonal FOXP3 Antibody
  • FOXP3抗体,Mouse Monoclonal FOXP3 Antibody
  • FOXP3抗体,Mouse Monoclonal FOXP3 Antibody

FOXP3抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:FOXP3抗体英文名称:Mouse Monoclonal FOXP3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 806 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: FOXP3
2025-05-10 FOXP3抗体 Mouse Monoclonal FOXP3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 806 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rabbit
IF咨询技术 Human,Mouse,Rabbit
IHC1/100 - 1/500 Human,Mouse,Rabbit
ICC技术咨询 Human,Mouse,Rabbit
FCM1/200 - 1/400 Human,Mouse,Rabbit
Elisa1/10000 Human,Mouse,Rabbit
   

产品详情

AliasesJM2; AIID; IPEX; PIDX; XPID; DIETER
Entrez GeneID50943
clone4F12A2
WB Predicted band size47.3kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rabbit
ImmunogenPurified recombinant fragment of human FOXP3 (AA: 297-431) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using FOXP3 mouse mAb against C2C12(1) Hela(2)Jurkat(3) cell lysate.    


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       Flow cytometric analysis of HeLa cells using FOXP3 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using FOXP3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using FOXP3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using FOXP3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rabbit spinal cord using FOXP3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rabbit cerebellum using FOXP3 mouse mAb with DAB staining.    


           

参考文献

以下是关于FOXP3抗体的3篇代表性文献,按发表时间排序:

1. **文献名称**:*Control of regulatory T cell development by the transcription factor Foxp3*

**作者**:Hori, S., Nomura, T., & Sakaguchi, S.

**摘要**:该研究首次克隆了小鼠Foxp3基因,证明其在调节性T细胞(Treg)中的特异性表达,并发现Foxp3缺失会导致小鼠自身免疫疾病,为后续FOXP3抗体的开发提供了理论基础。

2. **文献名称**:*Foxp3 programs the development and function of CD4+CD25+ regulatory T cells*

**作者**:Fontenot, J.D., Gavin, M.A., & Rudensky, A.Y.

**摘要**:通过基因工程和抗体标记技术,揭示了Foxp3对Treg细胞发育和功能的关键调控作用,并验证了FOXP3抗体在流式细胞术和免疫组化中的应用价值。

3. **文献名称**:*Specificity of FOXP3 antibodies in human tissues and cells: Critical assessment for accurate Treg identification*

**作者**:Allan, S.E., et al.

**摘要**:系统评估了多种市售FOXP3抗体在人类样本中的特异性,指出部分抗体存在交叉反应性,强调了选择可靠抗体对Treg细胞精准检测的重要性。

这些文献涵盖了FOXP3的功能机制、抗体开发及实际应用中的关键技术挑战,是相关领域的基础参考资料。

       

背景信息

The FOXP3 antibody is a crucial tool in immunology research, targeting the FOXP3 (Forkhead Box P3) protein, a transcription factor primarily expressed in regulatory T cells (Tregs). Discovered in the early 2000s, FOXP3 is a master regulator of Treg development and function, essential for maintaining immune tolerance and preventing autoimmune diseases. Mutations in the FOXP3 gene cause IPEX syndrome (Immune dysregulation, Polyendocrinopathy, Enteropathy, X-linked), highlighting its biological significance.

FOXP3 antibodies enable the identification and study of Tregs in both human and murine models. They are widely used in techniques like flow cytometry, immunohistochemistry, and Western blotting to detect FOXP3 expression, quantify Treg populations, or assess their functional status in tissues. These antibodies have advanced research in cancer immunology, autoimmune disorders (e.g., rheumatoid arthritis, type 1 diabetes), and transplantation, where Treg dysregulation plays a key role.

Commercial FOXP3 antibodies vary in specificity, targeting different epitopes (e.g., N-terminal or C-terminal regions) and showing species cross-reactivity differences. Validation is critical, as FOXP3 expression can be transient or heterogeneous in activated T cells. Additionally, FOXP3 antibodies have diagnostic potential, with clinical studies exploring Treg levels as biomarkers for disease progression or therapeutic responses. Their utility continues to grow with the development of Treg-targeted therapies and precision immunology approaches.

       
关键字: FOXP3抗体;FOXP3;FOXP3 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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