HDAC6抗体

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of Hela cells using HDAC6 mouse mAb (green) and negative control (red).    

  
  

Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family, primarily localized in the cytoplasm and involved in regulating non-histone substrates. Unlike other HDACs, HDAC6 contains two catalytic domains and a zinc finger motif, enabling its role in key cellular processes such as microtubule dynamics, protein aggregation clearance, and stress response. It specifically deacetylates α-tubulin, HSP90. and cortactin, influencing cell motility, intracellular transport, and immune signaling.

HDAC6 antibodies are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to quantify HDAC6 levels or assess its activity in disease models. Researchers leverage HDAC6-specific antibodies to explore its involvement in cancer progression, neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s diseases), and inflammatory conditions, where HDAC6 dysregulation is often observed.

The development of selective HDAC6 inhibitors has spurred interest in HDAC6-targeted therapies, emphasizing the need for reliable antibodies to validate drug efficacy and mechanism of action. Additionally, HDAC6 antibodies aid in deciphering its role in autophagy and aggresome formation, processes critical for cellular homeostasis. As HDAC6’s non-histone substrates and cytoplasmic functions continue to be uncovered, its antibodies remain pivotal for advancing research into targeted epigenetic and cytoskeleton-modulating therapies.