CD183抗体,Mouse Monoclonal CD183 Antibody
  • CD183抗体,Mouse Monoclonal CD183 Antibody
  • CD183抗体,Mouse Monoclonal CD183 Antibody
  • CD183抗体,Mouse Monoclonal CD183 Antibody

CD183抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:CD183抗体英文名称:Mouse Monoclonal CD183 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1028 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: CD183
2025-05-10 CD183抗体 Mouse Monoclonal CD183 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1028 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesCXCR3; GPR9; MigR; CD182; Mig-R; CKR-L2; CMKAR3; IP10-R
Entrez GeneID2833
clone5C10E6
WB Predicted band size40.7kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD183 (AA: extra mix) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using CD183 mouse mAb against Hela (1) and L-02 (2) cell lysate.    


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       Flow cytometric analysis of Jurkat cells using CD183 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of Ramos cells using CD183 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using CD183 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using CD183 mouse mAb with DAB staining.    


           

参考文献

以下是关于CD183(CXCR3)抗体的3篇文献摘要概览:

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1. **文献名称**:*CXCR3-targeted therapies in autoimmune diseases*

**作者**:Antonelli, A., et al. (2018)

**摘要**:探讨CXCR3在自身免疫疾病(如类风湿性关节炎、多发性硬化症)中的病理作用,分析其抗体在抑制T细胞迁移和炎症反应中的治疗潜力,并总结临床前及临床试验进展。

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2. **文献名称**:*CXCR3 ligands in disease-related leukocyte trafficking*

**作者**:Groom, J.R., & Richter, M.V. (2019)

**摘要**:研究CXCR3与其配体(CXCL9/10/11)的相互作用机制,阐明其在感染和肿瘤微环境中调控免疫细胞迁移的作用,并讨论抗体阻断策略对免疫调节的影响。

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3. **文献名称**:*CD183 as a biomarker for T cell activation in viral infections*

**作者**:Liu, L., et al. (2020)

**摘要**:通过流式细胞术分析CD183抗体标记的T细胞亚群,发现其在HIV和HCV患者中高表达,提示CXCR3可作为评估抗病毒免疫应答的动态生物标志物。

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**备注**:若需具体文献来源,建议通过PubMed或Google Scholar检索标题或作者名获取全文。

       

背景信息

CD183. also known as CXCR3. is a chemokine receptor belonging to the G protein-coupled receptor (GPCR) family. It is primarily expressed on activated T cells, natural killer (NK) cells, and other immune cells, where it mediates chemotaxis in response to interferon (IFN)-inducible ligands such as CXCL9. CXCL10. and CXCL11. These ligands are often upregulated during inflammatory or immune responses, positioning CD183 as a key player in directing immune cell migration to sites of infection, autoimmune activity, or tumor microenvironments.

CD183 antibodies are critical tools for identifying and characterizing CXCR3-expressing cell populations, particularly Th1-polarized T cells, which are associated with type 1 immune responses. In research, these antibodies are widely used in flow cytometry, immunohistochemistry, and functional studies to investigate immune dysregulation in diseases like multiple sclerosis, rheumatoid arthritis, viral infections, and cancer. Clinically, CD183 has emerged as a potential therapeutic target, with antibodies or small-molecule inhibitors being explored to modulate immune cell trafficking in inflammatory disorders. However, its role in cancer remains complex, as CXCR3 signaling can either promote antitumor immunity or facilitate tumor progression depending on context. Monoclonal anti-CD183 antibodies (e.g., clones 1C6. G025H7) are commonly validated for specificity across human and murine models, aiding mechanistic studies of immune pathways. Ongoing research continues to unravel its dualistic functions, balancing pro-inflammatory and regulatory roles in disease pathogenesis.

       
关键字: CD183抗体;CD183;CD183 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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