The KRT81 antibody targets keratin 81. a protein encoded by the *KRT81* gene, which belongs to the type II keratin family of intermediate filament proteins. Keratins are crucial structural components of epithelial cells, providing mechanical stability and resilience to tissues. Specifically, KRT81 pairs with type I keratins (e.g., KRT31. KRT35) to form heterodimers that assemble into filaments, predominantly expressed in hair follicles, nails, and other specialized epithelial structures. This keratin plays a vital role in maintaining the integrity of hair shafts and cuticles.
Antibodies against KRT81 are widely used in research to study hair biology, genetic disorders affecting keratinization, and epithelial differentiation. They are essential tools in immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting to localize and quantify KRT81 expression in tissues or cell lines. Dysregulation or mutations in *KRT81* have been linked to hair disorders, such as monilethrix and other congenital hair shaft abnormalities. Additionally, KRT81 overexpression has been observed in certain cancers, suggesting potential roles in tumor progression or epithelial-mesenchymal transition.
Commercial KRT81 antibodies are typically developed in hosts like rabbits or mice, validated for specificity through knockdown/knockout controls. Their applications span basic research, diagnostic pathology, and therapeutic target validation, underscoring their importance in dermatological and oncological studies.