The KRT31 antibody targets keratin 31. a protein encoded by the *KRT31* gene, which belongs to the type I keratin family. Keratins are intermediate filament proteins critical for maintaining structural integrity in epithelial cells, particularly in hair follicles, nails, and skin. KRT31 is an acidic keratin (type I) that pairs with basic keratins (type II) like KRT85 to form heterodimers, essential for hair shaft strength and resilience. Mutations in *KRT31* are linked to hereditary hair disorders such as monilethrix, characterized by brittle, beaded hair and follicular hyperkeratosis.
KRT31 antibodies are widely used in research to study hair biology, epithelial differentiation, and keratin-related pathologies. They enable detection of KRT31 expression in tissues via techniques like immunohistochemistry, Western blotting, and immunofluorescence. These tools help elucidate the protein's role in hair follicle cycling, wound healing, and diseases like ectodermal dysplasias. Commercially available KRT31 antibodies are typically raised in rabbits or mice, validated for specificity against human or model organism samples. Recent studies also explore KRT31's potential as a biomarker in certain cancers, given keratin dysregulation in epithelial malignancies. However, cross-reactivity with related keratins remains a technical consideration, necessitating careful experimental controls.