PNMT抗体

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: K562 cells, human liver cancer tissue, Jurkat cells, A549 cells, Primary antibody: P01656(PNMT Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

Phenylethanolamine N-methyltransferase (PNMT) is a critical enzyme in the catecholamine biosynthesis pathway, responsible for catalyzing the conversion of norepinephrine to epinephrine (adrenaline). It is predominantly expressed in the adrenal medulla and specific regions of the brain, such as the hypothalamus and brainstem. PNMT plays a vital role in the stress response, cardiovascular regulation, and energy metabolism by modulating epinephrine levels, a key hormone and neurotransmitter in sympathetic nervous system activation.

PNMT antibodies are immunological tools designed to detect and quantify PNMT expression in tissues or biological samples. These antibodies are widely used in neuroscience, endocrinology, and pharmacology research to investigate PNMT's distribution, regulation, and involvement in diseases. For instance, altered PNMT activity has been linked to hypertension, heart failure, and neuropsychiatric disorders like depression and anxiety. Researchers utilize PNMT antibodies in techniques such as Western blotting, immunohistochemistry, and ELISA to study enzyme expression patterns under physiological or pathological conditions, including stress, hypoxia, or drug interventions. Additionally, they aid in exploring epigenetic or genetic factors influencing PNMT transcription. High-specificity PNMT antibodies are essential for distinguishing PNMT from other catecholamine-synthesizing enzymes, ensuring accurate mechanistic insights into adrenergic signaling pathways and therapeutic target development.