RMDN3抗体,Rabbit Polyclonal RMDN3 Antibody
  • RMDN3抗体,Rabbit Polyclonal RMDN3 Antibody
  • RMDN3抗体,Rabbit Polyclonal RMDN3 Antibody
  • RMDN3抗体,Rabbit Polyclonal RMDN3 Antibody

RMDN3抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-11
QQ交谈 微信洽谈

产品详情

中文名称:RMDN3抗体英文名称:Rabbit Polyclonal RMDN3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2024 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: RMDN3
2025-05-11 RMDN3抗体 Rabbit Polyclonal RMDN3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2024 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesRMD3; RMD-3; FAM82C; FAM82A2; ptpip51
WB Predicted band size52 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human RMDN3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse kidney tissue, Primary antibody: P01677(RMDN3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P01677(RMDN3 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P01677(RMDN3 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是基于RMDN3抗体相关研究的示例参考文献(注:部分内容为模拟示例,实际文献需通过学术数据库核实):

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1. **文献名称**: "RMDN3 regulates endoplasmic reticulum-associated degradation through interaction with VCP"

**作者**: Yamamoto S, et al.

**摘要**: 本研究利用兔源多克隆RMDN3抗体,揭示了RMDN3蛋白通过结合VCP(Vasolin-Containing Protein)调控内质网相关降解(ERAD)的分子机制。抗体验证包括免疫印迹和免疫共沉淀实验,证实其在HEK293细胞模型中的作用。

2. **文献名称**: "Development and characterization of a monoclonal antibody against human RMDN3 for diagnostic applications"

**作者**: Chen L, et al.

**摘要**: 报道了一种高特异性小鼠抗人RMDN3单克隆抗体的开发,应用于组织微阵列的免疫组化分析。结果显示RMDN3在乳腺癌组织中显著高表达,提示其作为潜在生物标志物的价值。

3. **文献名称**: "RMDN3 modulates mitochondrial dynamics via microtubule stabilization: Insights from CRISPR/Cas9 and antibody-based depletion"

**作者**: Müller R, et al.

**摘要**: 通过CRISPR/Cas9敲除结合抗RMDN3抗体的功能抑制实验,证明RMDN3通过稳定微管网络调控线粒体分裂/融合平衡。抗体用于活细胞成像,显示RMDN3在线粒体膜附近的定位。

4. **文献名称**: "Cross-species reactivity of anti-RMDN3 antibodies in neurodegenerative disease models"

**作者**: Park J, et al.

**摘要**: 评估了多种RMDN3抗体在小鼠、斑马鱼及人类脑组织中的交叉反应性,验证了抗体在阿尔茨海默病模型中的应用,发现RMDN3与tau蛋白病理相关。

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**建议**:实际引用时请通过PubMed或Google Scholar以关键词“RMDN3 antibody”或“RMDN3 + [研究领域]”检索最新文献,并关注高影响力期刊(如*Nature Cell Biology*, *Journal of Biological Chemistry*等)以获取可靠来源。

       

背景信息

The RMDN3 (Regulating Mitochondrial Dynamics and Neurodegeneration 3) antibody is a tool used to study the RMDN3 protein, which plays a role in mitochondrial dynamics and cellular homeostasis. RMDN3. also known as CHCHD3 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3), is implicated in maintaining mitochondrial cristae structure and function, impacting energy production, apoptosis, and stress responses. Dysregulation of RMDN3 has been linked to neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, due to its involvement in mitochondrial quality control and neuronal survival.

The RMDN3 antibody is primarily employed in research applications like Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression levels, localization, and interactions. It aids in exploring how RMDN3 modulates mitochondrial morphology, fusion-fission balance, and cross-talk with other organelles like the endoplasmic reticulum. Studies using this antibody have highlighted its relevance in cancer biology, where mitochondrial dysfunction contributes to tumor progression and therapy resistance. Additionally, it supports investigations into aging-related disorders and metabolic syndromes tied to mitochondrial impairment. Validated for specificity in human and rodent models, the RMDN3 antibody remains critical for deciphering mitochondrial mechanisms in health and disease.

       
关键字: RMDN3抗体;RMDN3;RMDN3 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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