RRBP1 (Ribosome Binding Protein 1), also known as Ribophorin II, is a type I transmembrane protein primarily located in the rough endoplasmic reticulum (ER). It plays a critical role in ribosome binding and protein biosynthesis, particularly in the processing of secretory and membrane-bound proteins. As a component of the oligosaccharyltransferase complex, RRBP1 facilitates N-linked glycosylation, a post-translational modification essential for protein folding, stability, and cellular localization.
Antibodies targeting RRBP1 are widely used in research to study its expression, localization, and function in physiological and pathological contexts. These antibodies are critical tools for detecting RRBP1 via techniques like immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting. Studies have linked RRBP1 overexpression to various cancers, including breast, colorectal, and lung carcinomas, where it may promote tumor progression by enhancing ER stress adaptation or regulating oncogenic signaling pathways. Additionally, RRBP1 has been implicated in neurodegenerative diseases, potentially through its interaction with misfolded proteins.
Available as monoclonal or polyclonal variants, RRBP1 antibodies are often raised in rabbits or mice. Researchers rely on them to explore ER dynamics, protein quality control mechanisms, and disease biomarkers. Validation for specificity and cross-reactivity is crucial, as RRBP1 shares structural homology with other ER-resident proteins. Its study continues to shed light on cellular stress responses and therapeutic targets.