SPRY2抗体

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using PIGR mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using PIGR mouse mAb with DAB staining.    

  
  

**Background of SPRY2 Antibody**

The SPRY2 (Sprouty RTK Signaling Antagonist 2) antibody is a crucial tool for studying the SPRY2 protein, a member of the Sprouty family known for regulating receptor tyrosine kinase (RTK) signaling pathways. SPRY2 acts as a negative feedback modulator, primarily inhibiting the MAPK/ERK cascade by interacting with key components like Raf-1 and GRB2. thereby fine-tuning cellular responses to growth factors. Dysregulation of SPRY2 has been implicated in various cancers, where it often exhibits tumor-suppressive or oncogenic roles depending on context, such as in lung, breast, and prostate cancers.

SPRY2 antibodies are widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to detect SPRY2 expression, localization, and interactions in tissues or cultured cells. These antibodies are essential for investigating SPRY2's role in development, tissue homeostasis, and diseases, including fibrosis and neurodegenerative disorders. Commercial SPRY2 antibodies are typically raised in rabbits or mice, with validation via knockout controls or siRNA knockdown to ensure specificity.

Recent studies highlight SPRY2's emerging importance in cancer diagnostics and therapeutics, where its expression levels correlate with prognosis or drug resistance. Researchers also leverage SPRY2 antibodies to explore its crosstalk with pathways like PI3K/AKT and Hippo, revealing its broader regulatory network. As SPRY2 continues to be a focal point in cellular signaling research, high-quality antibodies remain vital for advancing mechanistic insights and translational applications.