**Background of TAF11 Antibody**
TAF11 (TATA-box binding protein-associated factor 11) is a subunit of the transcription factor TFIID complex, which plays a critical role in RNA polymerase II-mediated transcription initiation. As part of the TFIID complex, TAF11 interacts with other TAF proteins and core promoter elements to facilitate the assembly of the pre-initiation complex, ensuring precise regulation of gene expression. TAF11 is also implicated in chromatin remodeling, cell cycle progression, and apoptosis, with studies linking its dysregulation to cancers, viral infection responses, and developmental disorders.
Antibodies targeting TAF11 are essential tools for investigating its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to study TAF11's role in transcription mechanisms or disease contexts. For example, TAF11 antibodies have helped uncover its overexpression in certain cancers (e.g., prostate cancer) and its involvement in viral replication processes (e.g., HIV). Additionally, these antibodies aid in exploring TAF11's partnership with histone-fold domain proteins to stabilize the TFIID structure.
Research using TAF11 antibodies continues to advance understanding of transcriptional dysregulation in pathologies, offering potential insights for therapeutic targeting.