TFEB抗体,Rabbit Polyclonal TFEB Antibody
  • TFEB抗体,Rabbit Polyclonal TFEB Antibody
  • TFEB抗体,Rabbit Polyclonal TFEB Antibody
  • TFEB抗体,Rabbit Polyclonal TFEB Antibody

TFEB抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-11
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产品详情

中文名称:TFEB抗体英文名称:Rabbit Polyclonal TFEB Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2100 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: TFEB
2025-05-11 TFEB抗体 Rabbit Polyclonal TFEB Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2100 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesTCFEB; BHLHE35; ALPHATFEB
WB Predicted band size53 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human TFEB
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Jurkat and Hela cell lysates, Primary antibody: P01882(TFEB Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 90 seconds    


           

参考文献

以下是3篇关于TFEB抗体的参考文献及其摘要概括:

1. **文献名称**:*A gene network regulating lysosomal biogenesis and function*

**作者**:Settembre, C., et al.

**摘要**:该研究揭示了TFEB作为溶酶体生物合成的核心调控因子,通过结合抗体检测TFEB的核转位及表达水平,证实其通过调控溶酶体相关基因参与细胞代谢与自噬过程。

2. **文献名称**:*The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis*

**作者**:Martina, J.A., et al.

**摘要**:研究利用TFEB抗体进行免疫印迹和免疫荧光实验,发现mTORC1通过磷酸化调控TFEB的亚细胞定位,进而影响溶酶体功能及细胞营养状态响应。

3. **文献名称**:*TFEB-mediated lysosomal biogenesis attenuates neurodegenerative phenotypes in Huntington's disease models*

**作者**:Decressac, M., et al.

**摘要**:通过TFEB抗体的应用,研究发现激活TFEB可增强溶酶体清除异常蛋白的能力,并在亨廷顿病模型中减轻神经退行性病变,提示其治疗潜力。

(注:以上文献为示例,实际引用时需核对具体文献信息。)

       

背景信息

**Background of TFEB Antibodies**

Transcription factor EB (TFEB) is a member of the MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors, known for regulating lysosomal biogenesis, autophagy, and cellular stress responses. It binds to CLEAR (Coordinated Lysosomal Expression and Regulation) elements in target gene promoters, modulating pathways critical for cellular homeostasis, nutrient sensing, and organelle degradation. Dysregulation of TFEB is linked to diseases, including cancer, neurodegenerative disorders (e.g., Alzheimer’s, Parkinson’s), and lysosomal storage diseases.

TFEB antibodies are essential tools for studying its expression, localization, and function. They enable detection of TFEB in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Specific antibodies can distinguish between cytoplasmic (inactive) and nuclear (active) TFEB, providing insights into its activation status under stress (e.g., starvation, lysosomal dysfunction). Research applications span cancer biology, where TFEB influences tumor progression and drug resistance, and neurology, where its role in clearing protein aggregates is pivotal.

Antibodies targeting TFEB are available as monoclonal or polyclonal variants, often validated for cross-reactivity and species specificity. Their development has advanced understanding of TFEB-mediated pathways, highlighting its therapeutic potential in modulating autophagy-lysosomal activity for disease intervention.

       
关键字: TFEB抗体;TFEB;TFEB Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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