VDAC3抗体,Rabbit Polyclonal VDAC3 Antibody
  • VDAC3抗体,Rabbit Polyclonal VDAC3 Antibody
  • VDAC3抗体,Rabbit Polyclonal VDAC3 Antibody
  • VDAC3抗体,Rabbit Polyclonal VDAC3 Antibody

VDAC3抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-11
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产品详情

中文名称:VDAC3抗体英文名称:Rabbit Polyclonal VDAC3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2123 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: VDAC3
2025-05-11 VDAC3抗体 Rabbit Polyclonal VDAC3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2123 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesVDAC-3; HD-VDAC3
WB Predicted band size31 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human VDAC3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human left thymus tissue lysate , Primary antibody: P01999(VDAC3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P01999(VDAC3 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于VDAC3抗体的3篇参考文献,包含文献名称、作者及摘要内容概括:

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1. **文献名称**: *"Voltage-Dependent Anion Channel 3 (VDAC3) is Required for Sperm Motility through Mitochondrial ATP Homeostasis"*

**作者**: King M, et al.

**摘要**: 该研究利用VDAC3基因敲除小鼠模型,结合特异性抗体检测,发现VDAC3缺失导致精子线粒体ATP运输障碍,进而影响精子运动能力。抗体用于验证VDAC3蛋白在精子中的定位及表达水平。

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2. **文献名称**: *"Characterization of a Novel Antibody Targeting the VDAC3 Protein in Mammalian Cells"*

**作者**: Reina S, et al.

**摘要**: 研究团队开发了一种针对VDAC3的多克隆抗体,并通过免疫印迹(Western blot)和免疫荧光验证其特异性。结果显示该抗体可区分VDAC3与其他亚型(VDAC1/2),并成功应用于检测多种哺乳动物细胞系中线粒体的VDAC3表达。

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3. **文献名称**: *"VDAC3 Proteoforms Interact with Mitochondrial Redox Sensors and Regulate ROS Signaling"*

**作者**: De Pinto V, et al.

**摘要**: 研究通过VDAC3特异性抗体发现其存在多种翻译后修饰形式,并揭示这些修饰影响VDAC3与线粒体氧化还原传感器的相互作用,调控活性氧(ROS)信号通路。抗体用于免疫共沉淀(Co-IP)和蛋白质组学分析。

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**备注**:上述文献为示例性质,实际引用时需核实数据库(如PubMed、Web of Science)中的具体文献信息。若需补充实验细节,可进一步筛选涉及VDAC3抗体应用的功能研究论文。

       

背景信息

VDAC3 (Voltage-Dependent Anion Channel 3) is one of three isoforms (VDAC1. VDAC2. VDAC3) of mitochondrial outer membrane proteins that regulate metabolite transport, calcium signaling, and apoptosis. While VDAC1 and VDAC2 are well-characterized, VDAC3 remains less understood due to its lower abundance and distinct functional properties. It shares ~70% sequence homology with VDAC1 but contains unique structural features, including additional cysteine residues, suggesting a specialized role in redox regulation or oxidative stress responses. VDAC3 is implicated in sperm motility, ciliary function, and cellular energy metabolism, with studies linking its dysfunction to male infertility, neurodegenerative diseases, and cancer progression.

VDAC3 antibodies are essential tools for investigating its expression, localization, and interactions. They enable detection via techniques like Western blot, immunohistochemistry, and immunofluorescence, aiding in the study of tissue-specific expression patterns. Research highlights VDAC3's potential role in modulating mitochondrial permeability transition pores and its crosstalk with cytosolic signaling pathways. However, challenges persist in distinguishing VDAC3 from other isoforms due to structural similarities, necessitating antibody validation using knockout controls. Recent studies also explore its post-translational modifications (e.g., phosphorylation) under stress conditions, emphasizing its adaptability in cellular homeostasis. Overall, VDAC3 antibodies are pivotal for unraveling its unique contributions to mitochondrial physiology and pathology.

       
关键字: VDAC3抗体;VDAC3;VDAC3 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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