The leucine-rich repeat-containing protein 19 (LRRC19) is a member of the leucine-rich repeat (LRR) superfamily, characterized by repetitive structural motifs involved in protein-protein interactions and cellular signaling. LRRC19 is a transmembrane protein predominantly expressed in immune cells, epithelial tissues, and certain cancers. Its exact biological role remains under investigation, but studies suggest involvement in innate immune responses, inflammation regulation, and cell adhesion. LRRC19 has been linked to Toll-like receptor (TLR) signaling pathways, potentially modulating NF-κB activation and cytokine production.
LRRC19-specific antibodies are critical tools for studying its expression patterns, subcellular localization, and functional mechanisms. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and flow cytometry, aiding research into LRRC19's role in diseases such as colorectal cancer, where its overexpression correlates with tumor progression, or inflammatory bowel disease (IBD), where dysregulation may contribute to pathogenesis. Commercial and custom antibodies are typically generated using recombinant LRRC19 protein fragments or peptide immunogens, with validation including knockout cell line controls to ensure specificity. Ongoing research aims to clarify LRRC19's interactions with other immune regulators and its potential as a therapeutic target or diagnostic biomarker.