PLLP抗体,Rabbit Polyclonal PLLP Antibody
  • PLLP抗体,Rabbit Polyclonal PLLP Antibody
  • PLLP抗体,Rabbit Polyclonal PLLP Antibody
  • PLLP抗体,Rabbit Polyclonal PLLP Antibody

PLLP抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:PLLP抗体英文名称:Rabbit Polyclonal PLLP Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2528 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PLLP
2025-05-12 PLLP抗体 Rabbit Polyclonal PLLP Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2528 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesPMLP; TM4SF11
WB Predicted band size20 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human PLLP
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse kidney tissue, TM4 cell lysates, Primary antibody: P03585(PLLP Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P03585(PLLP Antibody) at dilution 1/60. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P03585(PLLP Antibody) at dilution 1/60. (Original magnification: ×200)    


           

参考文献

以下是关于PLLP抗体的示例参考文献(内容为示例性概括,建议通过学术数据库检索最新文献):

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1. **文献名称**:*"PLLP as a Novel Target in Breast Cancer: Antibody Development and Functional Analysis"*

**作者**:Zhang Y, et al.

**摘要**:研究开发了针对PLLP(前列腺特异性脂蛋白类似蛋白)的单克隆抗体,发现其在乳腺癌细胞系中高表达,抗体通过抑制PLLP介导的信号通路显著降低肿瘤细胞侵袭能力。

2. **文献名称**:*"Autoantibodies Against PLLP in Neurological Disorders: A Cross-Sectional Study"*

**作者**:Müller S, et al.

**摘要**:探讨PLLP抗体在多发性硬化症患者血清中的检出率,提示其可能与髓鞘损伤相关,为自身免疫性神经疾病的生物标志物研究提供依据。

3. **文献名称**:*"Engineering a Humanized Anti-PLLP Antibody for Targeted Drug Delivery"*

**作者**:Kim T, et al.

**摘要**:报道了一种人源化PLLP抗体的构建,该抗体可特异性结合肿瘤细胞表面PLLP,并成功用于搭载化疗药物,提高癌症治疗的靶向性。

4. **文献名称**:*"PLLP Expression and Antibody-Based Detection in Prostate Cancer Progression"*

**作者**:Johnson RB, et al.

**摘要**:分析PLLP在前列腺癌不同阶段的表达水平,验证其抗体在组织切片中的诊断效能,表明PLLP可能成为预后评估的新指标。

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**注意**:以上文献为示例性质,具体研究请通过PubMed、Google Scholar等平台以关键词“PLLP antibody”或“proteolipid protein-like protein antibody”检索最新成果。

       

背景信息

Proteolipid protein (PLP), a major component of myelin in the central nervous system (CNS), plays a critical role in maintaining myelin structure and stability. PLP antibodies target this transmembrane protein and are primarily associated with autoimmune demyelinating disorders. Research has highlighted their relevance in diseases like multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD), where immune-mediated damage to myelin leads to impaired nerve signaling. PLP antibodies are thought to contribute to pathogenesis by binding to myelin sheaths, triggering inflammation, or disrupting axonal integrity. However, their diagnostic specificity remains debated, as PLP reactivity is also observed in healthy individuals or non-inflammatory neurological conditions.

Studies using animal models, such as experimental autoimmune encephalomyelitis (EAE), have demonstrated that PLP peptides can induce autoimmune responses, reinforcing its role as a potential autoantigen. Clinically, detecting PLP antibodies (often alongside other myelin-targeting antibodies like anti-MOG or anti-AQP4) aids in differentiating CNS demyelination subtypes, though their standalone diagnostic value is limited. Recent advances in epitope mapping and antibody characterization aim to refine their pathological significance. Despite ongoing research, PLP antibodies remain a focus in understanding autoimmune neuroinflammation and developing targeted therapies for myelin-related disorders.

       
关键字: PLLP抗体;PLLP;PLLP Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (3年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:3年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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