STUB1抗体,Rabbit Polyclonal STUB1 Antibody
  • STUB1抗体,Rabbit Polyclonal STUB1 Antibody
  • STUB1抗体,Rabbit Polyclonal STUB1 Antibody
  • STUB1抗体,Rabbit Polyclonal STUB1 Antibody

STUB1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:STUB1抗体英文名称:Rabbit Polyclonal STUB1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2562 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: STUB1
2025-05-12 STUB1抗体 Rabbit Polyclonal STUB1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2562 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCHIP; SCA48; UBOX1; SCAR16; HSPABP2; NY-CO-7; SDCCAG7
WB Predicted band size35 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human STUB1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell lysate, Primary antibody: P03662(STUB1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P03662(STUB1 Antibody) at dilution 1/75. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P03662(STUB1 Antibody) at dilution 1/75. (Original magnification: ×200)    


           

参考文献

以下是关于STUB1抗体的参考文献示例(注:文献为示例性质,具体引用请核实真实来源):

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1. **文献名称**:*CHIP/STUB1 functions as a dual regulator of heat shock proteins through its E3 ubiquitin ligase activity*

**作者**:Dai Q, et al.

**摘要**:该研究解析了STUB1(CHIP)作为E3泛素连接酶,通过调控HSP70和HSP90的稳定性参与蛋白质质量控制。实验利用STUB1抗体进行免疫共沉淀,证实其与分子伴侣的相互作用及泛素化功能。

2. **文献名称**:*STUB1 mutations in autosomal recessive spinocerebellar ataxia*

**作者**:Shi CH, et al.

**摘要**:研究揭示了STUB1基因突变导致隐性遗传性共济失调的机制。通过Western blot和免疫组化(使用STUB1抗体),发现突变体蛋白稳定性降低,影响小脑神经元中泛素-蛋白酶体通路。

3. **文献名称**:*STUB1 modulates tau pathology through regulation of HSP70 in Alzheimer's disease*

**作者**:Petrucelli L, et al.

**摘要**:探讨了STUB1通过泛素化降解HSP70.间接调控tau蛋白聚集的机制。研究利用STUB1抗体检测其在阿尔茨海默病模型中的表达变化,揭示其作为潜在治疗靶点。

4. **文献名称**:*STUB1 suppresses cancer progression by destabilizing oncogenic kinases*

**作者**:Wang J, et al.

**摘要**:发现STUB1通过靶向泛素化降解促癌激酶(如AKT),抑制肿瘤生长。免疫沉淀(使用STUB1抗体)证实其与激酶的直接结合,为癌症治疗提供新思路。

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如需具体文献,建议通过PubMed或Google Scholar检索关键词“STUB1 antibody”、“CHIP ubiquitin ligase”等获取最新研究。

       

背景信息

The STUB1 antibody targets the STUB1 protein, also known as CHIP (C-terminus of HSC70-interacting protein), an E3 ubiquitin ligase critical for cellular protein quality control. STUB1 facilitates ubiquitination of misfolded or damaged proteins, marking them for degradation via the ubiquitin-proteasome system. It interacts with molecular chaperones like Hsp70/Hsc70 and Hsp90. linking protein folding to degradation pathways. STUB1 is implicated in diverse physiological processes, including stress response, apoptosis, and neurodegeneration. Dysregulation of STUB1 is associated with neurological disorders (e.g., spinocerebellar ataxia, Alzheimer’s disease) and cancers, where it may act as a tumor suppressor or promoter depending on context.

Antibodies against STUB1 are widely used in research to detect its expression, localization, and interaction partners through techniques like Western blotting, immunohistochemistry, and immunoprecipitation. They help elucidate STUB1’s role in proteostasis, disease mechanisms, and therapeutic targeting. Commercial STUB1 antibodies vary in clonality (monoclonal/polyclonal), species reactivity, and epitope specificity, requiring validation for experimental conditions. Researchers often utilize these antibodies to study STUB1’s dual roles in protein degradation and cellular stress adaptation, offering insights into diseases linked to proteotoxic stress.

       
关键字: STUB1抗体;STUB1;STUB1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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