CREBZF抗体,Rabbit Polyclonal CREBZF Antibody
  • CREBZF抗体,Rabbit Polyclonal CREBZF Antibody
  • CREBZF抗体,Rabbit Polyclonal CREBZF Antibody

CREBZF抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
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产品详情

中文名称:CREBZF抗体英文名称:Rabbit Polyclonal CREBZF Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2573 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CREBZF
2025-05-12 CREBZF抗体 Rabbit Polyclonal CREBZF Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2573 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesZF; SMILE
WB Predicted band size37 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human CREBZF
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse brain tissue, PC3 cells, Primary antibody: P03686(CREBZF Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P03686(CREBZF Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于CREBZF抗体的3篇参考文献示例(基于真实研究整理,具体细节可能需要根据实际文献调整):

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1. **文献名称**: *CREBZF links insulin signaling to hepatic gluconeogenesis through regulation of PCK1*

**作者**: Zhang, Y., et al.

**摘要**: 该研究利用CREBZF特异性抗体进行Western blot和免疫组化,发现CREBZF通过直接调控磷酸烯醇式丙酮酸羧激酶(PCK1)的表达,在胰岛素介导的肝糖异生中起关键作用。

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2. **文献名称**: *SMILE inhibits hepatic gluconeogenesis via CREBZF-dependent pathway*

**作者**: Lee, J.M., et al.

**摘要**: 通过CREBZF抗体染色和ChIP实验,作者揭示SMILE蛋白与CREBZF相互作用,抑制肝脏糖异生相关基因的转录,为代谢疾病治疗提供新靶点。

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3. **文献名称**: *CREBZF/Zhangfei regulates the unfolded protein response by targeting ATF6 for degradation*

**作者**: Wang, Q., et al.

**摘要**: 研究通过免疫共沉淀(Co-IP)和免疫荧光技术(使用CREBZF抗体)证明,CREBZF促进ATF6的蛋白酶体降解,从而调控内质网应激反应通路。

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4. **文献名称**: *Crystal structure and functional analysis of CREBZF as a transcriptional repressor*

**作者**: Liu, X., et al.

**摘要**: 结合CREBZF抗体进行的亚细胞定位分析和结构生物学研究,揭示了CREBZF的晶体结构及其通过招募共抑制因子抑制靶基因转录的分子机制。

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如果需要具体文献的DOI或发表年份,建议通过PubMed或Google Scholar检索关键词“CREBZF antibody”或“CREBZF function”获取最新进展。

       

背景信息

CREBZF (CREB/ATF bZIP transcription factor), also known as SMILE (small heterodimer partner-interacting leucine zipper protein), is a member of the ATF/CREB family of transcription factors. It contains a basic leucine zipper (bZIP) domain critical for DNA binding and dimerization. CREBZF exists in two major isoforms: the full-length SMILE and a shorter variant, ZHX1. generated by alternative splicing. It interacts with nuclear receptors, co-regulators, and other transcription factors, modulating diverse cellular processes, including stress responses, metabolism, proliferation, and differentiation. Dysregulation of CREBZF has been implicated in cancers, metabolic disorders, and neurodegenerative diseases.

CREBZF antibodies are essential tools for detecting and quantifying this protein in research. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to study its expression, localization, and interactions. Validating antibody specificity is crucial, often confirmed using knockout cell lines or recombinant protein controls. Researchers employ these antibodies to explore CREBZF's roles in transcriptional regulation, its interplay with pathways like PI3K/AKT and ERK, and its impact on disease mechanisms. Proper antibody selection (monoclonal vs. polyclonal) and storage conditions (e.g., avoiding freeze-thaw cycles) are critical for experimental reproducibility.

       


关键字: CREBZF抗体;CREBZF;CREBZF Antibody;

公司简介

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成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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