ABCB9抗体,Rabbit Polyclonal ABCB9 Antibody
  • ABCB9抗体,Rabbit Polyclonal ABCB9 Antibody
  • ABCB9抗体,Rabbit Polyclonal ABCB9 Antibody
  • ABCB9抗体,Rabbit Polyclonal ABCB9 Antibody

ABCB9抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:ABCB9抗体英文名称:Rabbit Polyclonal ABCB9 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2582 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: ABCB9
2025-05-12 ABCB9抗体 Rabbit Polyclonal ABCB9 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2582 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/15-1/50 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesTAPL, EST122234
WB Predicted band size84 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human ABCB9
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: P03710(ABCB9 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P03710(ABCB9 Antibody) at dilution 1/15. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P03710(ABCB9 Antibody) at dilution 1/15. (Original magnification: ×200)    


           

参考文献

以下是关于ABCB9抗体的3篇参考文献示例(注:以下文献为模拟内容,实际引用请核实真实来源):

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1. **文献名称**: *ABCB9 mediates lysosomal transport of phospholipids through interactions with the LIMP-2/SCARB2 complex*

**作者**: Ishikawa, T., et al.

**摘要**: 本研究利用特异性ABCB9抗体进行免疫荧光和免疫印迹分析,揭示了ABCB9在溶酶体膜上的定位。通过基因沉默和抗体阻断实验,发现ABCB9与LIMP-2蛋白相互作用,调控溶酶体内磷脂代谢,提示其在细胞内脂质稳态中的作用。

2. **文献名称**: *Differential expression of ABCB9 in colorectal cancer and its correlation with chemoresistance*

**作者**: Müller, S., et al.

**摘要**: 通过ABCB9抗体对结直肠癌组织进行免疫组化分析,发现ABCB9在化疗耐药患者中显著高表达。功能实验表明,ABCB9过表达通过调节溶酶体药物外排增强癌细胞耐药性,提示其作为潜在治疗靶点。

3. **文献名称**: *Generation and characterization of ABCB9 knockout mice using antibody-based phenotypic validation*

**作者**: Velarde, G., et al.

**摘要**: 研究构建了ABCB9基因敲除小鼠模型,利用Western blot和免疫组化抗体验证蛋白表达缺失。表型分析显示,ABCB9缺失导致溶酶体功能异常和脂质积累,支持其在脂质代谢中的关键作用。

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**备注**:以上文献为示例,实际研究中建议通过PubMed或Google Scholar检索最新文章。若需具体文献,可提供更详细的研究方向以便进一步筛选。

       

背景信息

ABCB9. a member of the ATP-binding cassette (ABC) transporter superfamily, is a transmembrane protein primarily localized to lysosomal membranes. It functions as an ATP-dependent transporter, facilitating the movement of specific substrates across membranes, though its exact physiological substrates remain under investigation. ABCB9 is structurally characterized by two nucleotide-binding domains (NBDs) and two transmembrane domains (TMDs), typical of ABC transporters, which hydrolyze ATP to drive substrate translocation. It is implicated in lysosomal homeostasis, potentially participating in antigen processing, peptide transport, or lipid metabolism, with studies suggesting a role in maintaining cellular stress responses.

ABCB9 antibodies are critical tools for detecting and quantifying ABCB9 protein expression in research. They enable the study of its subcellular localization, expression patterns across tissues, and regulatory mechanisms under physiological or pathological conditions. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Dysregulation of ABCB9 has been explored in cancer, neurodegenerative diseases, and lysosomal storage disorders, with its expression occasionally linked to drug resistance or disease progression. ABCB9 knockout models and inhibitor studies further rely on these antibodies to validate protein knockdown or functional inhibition. Despite progress, the precise biological roles of ABCB9 and its relevance to human diseases remain areas of active research, highlighting the continued importance of high-specificity antibodies in unraveling its molecular and therapeutic significance.

       
关键字: ABCB9抗体;ABCB9;ABCB9 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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