ADRA1B抗体,Rabbit Polyclonal ADRA1B Antibody
  • ADRA1B抗体,Rabbit Polyclonal ADRA1B Antibody
  • ADRA1B抗体,Rabbit Polyclonal ADRA1B Antibody
  • ADRA1B抗体,Rabbit Polyclonal ADRA1B Antibody

ADRA1B抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
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产品详情

中文名称:ADRA1B抗体英文名称:Rabbit Polyclonal ADRA1B Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2594 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: ADRA1B
2025-05-12 ADRA1B抗体 Rabbit Polyclonal ADRA1B Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2594 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesADRA1, ALPHA1BAR
WB Predicted band size57 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human ADRA1B
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human lung cancer tissue, Primary antibody: P03771(ADRA1B Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P03771(ADRA1B Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P03771(ADRA1B Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于ADRA1B抗体的3篇参考文献的简要信息(注:文献信息为示例性概括,具体内容需通过学术数据库核实):

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1. **文献名称**: "Characterization of α1B-adrenergic receptor phosphorylation and desensitization"

**作者**: Garcia-Sainz, J.A., et al.

**摘要**: 研究通过Western blot和免疫荧光技术,利用特异性ADRA1B抗体分析了肾上腺素受体α1B亚型在细胞膜上的分布及其磷酸化调控机制,揭示其在G蛋白偶联受体信号转导中的动态变化。

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2. **文献名称**: "ADRA1B modulates cancer cell proliferation via PKC/MAPK pathways"

**作者**: Zhao, Y., et al.

**摘要**: 该研究使用ADRA1B特异性抗体进行免疫组化和流式细胞术,发现ADRA1B在多种癌细胞系中高表达,并通过激活PKC和MAPK通路促进肿瘤细胞增殖,提示其作为潜在治疗靶点。

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3. **文献名称**: "Tissue-specific expression of α1-adrenergic receptor subtypes"

**作者**: Michelotti, G.A., et al.

**摘要**: 通过比较不同组织(如心脏、肝脏、脑)中α1肾上腺素受体亚型的表达差异,利用ADRA1B抗体进行免疫印迹分析,证实ADRA1B在中枢神经系统和血管平滑肌中的高表达及其生理意义。

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4. **文献名称**: "Targeted deletion of ADRA1B alters behavioral responses to stress"

**作者**: Tanoue, A., et al.

**摘要**: 研究通过ADRA1B基因敲除小鼠模型,结合抗体验证蛋白表达缺失,发现ADRA1B缺失导致小鼠对急性应激的行为反应异常,表明其在交感神经应激调控中的关键作用。

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建议通过PubMed或Google Scholar输入关键词(如“ADRA1B antibody”、“alpha1B-adrenergic receptor”)获取原文核实。

       

背景信息

The ADRA1B antibody targets the alpha-1B-adrenergic receptor (ADRA1B), a G protein-coupled receptor (GPCR) primarily activated by catecholamines like epinephrine and norepinephrine. ADRA1B is one of three subtypes (ADRA1A, ADRA1B, ADRA1D) within the alpha-1-adrenergic receptor family, which mediates physiological responses such as vasoconstriction, smooth muscle contraction, and modulation of neurotransmission. This receptor is predominantly expressed in the brain, liver, kidneys, and vascular smooth muscle, playing a role in regulating blood pressure, metabolic processes, and central nervous system functions.

ADRA1B antibodies are essential tools for studying receptor localization, expression levels, and signaling mechanisms in both normal and pathological conditions. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate ADRA1B's involvement in diseases such as hypertension, benign prostatic hyperplasia, and neurological disorders. Researchers also utilize these antibodies to explore receptor dynamics, including ligand binding, internalization, and interactions with downstream effectors.

Commercial ADRA1B antibodies are typically raised in hosts like rabbits or mice, with validation methods including knockout cell lines or tissues to confirm specificity. Challenges in antibody development arise from the structural homology among adrenergic receptor subtypes, necessitating rigorous cross-reactivity testing. Understanding ADRA1B's role through antibody-based research contributes to therapeutic advancements, particularly in designing subtype-selective drugs with minimized side effects.

       
关键字: ADRA1B抗体;ADRA1B;ADRA1B Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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