CDK11A/CDK11B抗体,Rabbit Polyclonal CDK11A/CDK11B Antibody
  • CDK11A/CDK11B抗体,Rabbit Polyclonal CDK11A/CDK11B Antibody
  • CDK11A/CDK11B抗体,Rabbit Polyclonal CDK11A/CDK11B Antibody
  • CDK11A/CDK11B抗体,Rabbit Polyclonal CDK11A/CDK11B Antibody

CDK11A/CDK11B抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
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产品详情

中文名称:CDK11A/CDK11B抗体英文名称:Rabbit Polyclonal CDK11A/CDK11B Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2625 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CDK11A/CDK11B
2025-05-12 CDK11A/CDK11B抗体 Rabbit Polyclonal CDK11A/CDK11B Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2625 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCDC2L2; CDC2L3; p58GTA; PITSLRE; CDK11-p46; CDK11-p58; CDK11-p110 / p58; PK58; CDK11; CLK-1; CDC2L1; p58CLK-1; CDK11-p46; CDK11-p58; p58CDC2L1; CDK11-p110
WB Predicted band size93 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human CDK11A/CDK11B
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela cells, hepG2 cells, lovo cells, human colon cancer tissue, Primary antibody: P04762(CDK11A/CDK11B Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04762(CDK11A/CDK11B Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P04762(CDK11A/CDK11B Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于CDK11A/CDK11B抗体的3篇参考文献的简要信息:

1. **文献名称**: *CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1*

**作者**: Greifenberg, A.K., et al.

**摘要**: 该研究利用CDK11特异性抗体,证明CDK11通过磷酸化剪接因子SF3B1调控前体mRNA剪接,其活性在细胞周期中动态变化,并与转录延伸偶联。

2. **文献名称**: *CDK11p58 is required for centrosome cohesion and spindle organization*

**作者**: Hu, D., et al.

**摘要**: 通过CDK11B(p58)抗体的免疫荧光实验,发现CDK11B在有丝分裂中维持中心体结构和纺锤体组装,敲低导致染色体分离异常。

3. **文献名称**: *CDK11 promotes transcriptional elongation by suppressing backtracking of RNA polymerase II*

**作者**: Chen, H.H., et al.

**摘要**: 研究使用CDK11A抗体进行ChIP-seq分析,揭示CDK11A通过阻止RNA聚合酶II倒退,促进基因转录延伸,尤其在癌基因表达中起关键作用。

*注:以上文献为示例性质,实际引用时需核对原文准确性。CDK11相关研究多聚焦其转录调控及癌症关联,抗体常应用于功能验证实验(如Western blot、免疫共沉淀)。*

       

背景信息

CDK11A and CDK11B, encoded by the homologous genes *CDK11A* (also known as *CDC2L2*) and *CDK11B* (*CDC2L1*), are serine/threonine kinases belonging to the cyclin-dependent kinase (CDK) family. These isoforms arise from alternative splicing of a common precursor mRNA and share ~97% amino acid sequence identity, differing primarily in their C-terminal regions. Both proteins interact with cyclin L to form active kinase complexes involved in regulating RNA transcription, splicing, and cell cycle progression, particularly during the G2/M phase. CDK11B, the more extensively studied isoform, plays critical roles in spindle assembly, sister chromatid cohesion, and apoptosis. Antibodies targeting CDK11A/B are essential tools for investigating their distinct and overlapping functions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study localization, protein interactions, and expression patterns in normal and diseased states. Due to their high sequence homology, antibody specificity validation is crucial to avoid cross-reactivity. Dysregulation of CDK11 signaling has been implicated in cancers, neurological disorders, and viral infections, making these antibodies valuable for both basic research and therapeutic target validation. Recent studies also highlight their potential role in modulating transcription elongation through phosphorylation of RNA polymerase II.
       
关键字: CDK11A/CDK11B抗体;CDK11A/CDK11B;CDK11A/CDK11B Antibo;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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