PHKG2抗体,Rabbit Polyclonal PHKG2 Antibody
  • PHKG2抗体,Rabbit Polyclonal PHKG2 Antibody
  • PHKG2抗体,Rabbit Polyclonal PHKG2 Antibody
  • PHKG2抗体,Rabbit Polyclonal PHKG2 Antibody

PHKG2抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:PHKG2抗体英文名称:Rabbit Polyclonal PHKG2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2755 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PHKG2
2025-05-12 PHKG2抗体 Rabbit Polyclonal PHKG2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2755 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesHL14
WB Predicted band size15 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human LGALS2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal intestines tissue and Mouse stomach tissue lysates, Primary antibody: P07310(LGALS2 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07310(LGALS2 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P07310(LGALS2 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于PHKG2抗体的参考文献示例(注:以下内容为模拟文献,实际引用时请核实真实来源):

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1. **"PHKG2 mutations and glycogen storage disease IX: A clinical and molecular study"**

*作者:Maurya S, et al. (2015)*

**摘要**:研究利用PHKG2特异性抗体分析患者肝组织,发现PHKG2基因突变导致蛋白表达缺失,与糖原贮存病IX型的代谢异常相关。

2. **"Dysregulation of PHKG2 in hepatocellular carcinoma: Role in metabolic reprogramming"**

*作者:Zhang Y, et al. (2018)*

**摘要**:通过PHKG2抗体进行免疫组化和Western blot,揭示肝癌组织中PHKG2表达下调,其缺失促进糖原累积并加速肿瘤生长。

3. **"Validation of a PHKG2-specific antibody for skeletal muscle phosphorylation studies"**

*作者:Brown KE, et al. (2020)*

**摘要**:验证了PHKG2抗体的特异性,并应用于骨骼肌样本,证明运动后PHKG2磷酸化水平升高,调控糖原分解活性。

4. **"PHKG2 modulates cardiac hypertrophy via energy metabolism pathways"**

*作者:Lee H, et al. (2019)*

**摘要**:使用PHKG2抗体检测心肌细胞,发现压力超负荷模型中PHKG2表达上调,可能通过改变磷酸化酶活性影响心力衰竭进程。

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**提示**:实际研究中,建议通过PubMed或Google Scholar以关键词“PHKG2 antibody”或“PHKG2 immunohistochemistry”检索最新文献,并优先选择经过抗体验证(如KO验证)的研究。

       

背景信息

The PHKG2 (Phosphorylase Kinase Gamma 2) antibody is a tool used to study the gamma-2 regulatory subunit of phosphorylase kinase, an enzyme critical for glycogen metabolism. PHKG2. encoded by the *PHKG2* gene, is part of the phosphorylase kinase complex, which activates glycogen phosphorylase to initiate glycogen breakdown. This complex comprises four subunits (α, β, γ, δ), with the γ-subunit (PHKG2) directly binding ATP to catalyze the phosphorylation and activation of glycogen phosphorylase. PHKG2 is primarily expressed in the liver and testis, suggesting roles beyond glycogenolysis, including potential involvement in sperm maturation or male fertility.

Mutations in *PHKG2* are linked to glycogen storage disease type IX (GSD IX), a rare inherited disorder characterized by hepatomegaly, growth delays, and fasting hypoglycemia due to impaired glycogen breakdown. Research using PHKG2 antibodies focuses on detecting protein expression in tissues, assessing its regulatory mechanisms, and exploring its pathological role in metabolic disorders. These antibodies are typically validated for applications like Western blotting, immunohistochemistry, and immunofluorescence.

In cancer biology, altered PHKG2 expression has been observed in hepatocellular carcinoma, though its exact role remains unclear. PHKG2 antibodies help investigate its interaction with other kinases or signaling pathways, contributing to broader studies on metabolic reprogramming in diseases. Specificity is crucial, as PHKG2 shares homology with PHKG1 (the gamma-1 isoform), requiring antibodies that distinguish between these isoforms. Overall, PHKG2 antibodies are vital for dissecting glycogen metabolism regulation and its implications in genetic and acquired diseases.

       
关键字: PHKG2抗体;PHKG2;PHKG2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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