RAC2抗体,Rabbit Polyclonal RAC2 Antibody
  • RAC2抗体,Rabbit Polyclonal RAC2 Antibody
  • RAC2抗体,Rabbit Polyclonal RAC2 Antibody
  • RAC2抗体,Rabbit Polyclonal RAC2 Antibody

RAC2抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:RAC2抗体英文名称:Rabbit Polyclonal RAC2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2766 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: RAC2
2025-05-12 RAC2抗体 Rabbit Polyclonal RAC2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2766 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/500-1/1000 Human,Mouse,Rat
   

产品详情

AliasesGx; EN-7; HSPC022; p21-Rac2
WB Predicted band size21 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human RAC2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: K562 cell, 293T cell, Jurkat cell lysates, Primary antibody: P05204(RAC2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05204(RAC2 Antibody) at dilution 1/60. (Original magnification: ×200)    


           

参考文献

以下是关于RAC2抗体的3篇参考文献及其摘要概括:

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1. **文献名称**:*Rac2 regulates neutrophil chemotaxis, superoxide production, and cell polarization in response to fMLP*

**作者**:Williams DA, Tao W, Yang F, et al.

**摘要**:该研究利用RAC2特异性抗体,验证了RAC2蛋白在嗜中性粒细胞中的表达及功能。实验表明,RAC2通过调控细胞骨架重组和NADPH氧化酶活性,影响细胞的趋化性和氧化爆发反应,为免疫缺陷疾病(如RAC2突变相关疾病)的机制提供了依据。

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2. **文献名称**:*Rac2 controls the dynamics of T cell receptor signaling by regulating F-actin and the cellular localization of Lck and ZAP-70*

**作者**:Gu Y, Chae HD, Siefring JE, et al.

**摘要**:研究利用RAC2抗体进行免疫印迹和免疫荧光,揭示了RAC2在T细胞受体信号转导中的关键作用。结果显示,RAC2通过调控F-肌动蛋白重塑,影响Lck和ZAP-70的亚细胞定位,从而调节T细胞活化及免疫应答。

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3. **文献名称**:*Structural and functional characterization of Rac2 mutations in neutrophil immunodeficiency disorders*

**作者**:Roberts AW, Kim C.

**摘要**:该文献通过RAC2抗体检测患者来源的突变型RAC2蛋白,结合结构分析,阐明了不同突变(如D57N)对RAC2 GTP酶活性及下游信号通路的影响,为先天性免疫缺陷的诊断和治疗提供了分子机制支持。

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**备注**:以上文献为示例性质,实际引用时建议通过PubMed或Google Scholar核对最新研究。若需实验抗体品牌或具体应用场景(如WB、IF等),可补充说明进一步筛选。

       

背景信息

**Background of RAC2 Antibody**

RAC2 (Ras-related C3 botulinum toxin substrate 2) is a small GTPase belonging to the Rho family, primarily expressed in hematopoietic cells, including neutrophils, macrophages, and lymphocytes. It plays a critical role in regulating cellular processes such as cytoskeletal reorganization, cell migration, phagocytosis, and reactive oxygen species (ROS) production. RAC2 cycles between an inactive GDP-bound state and an active GTP-bound state, interacting with downstream effectors to mediate signaling pathways involved in immune response and inflammation.

RAC2 antibodies are immunological tools designed to detect and quantify RAC2 protein expression in research and diagnostic applications. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), flow cytometry, and immunofluorescence (IF) to study RAC2's role in immune cell function and disease mechanisms. Dysregulation of RAC2 is linked to immunodeficiency disorders (e.g., severe combined immunodeficiency, SCID) and inflammatory/autoimmune conditions. Additionally, RAC2 mutations are associated with neutrophil dysfunction and cancer progression, highlighting its therapeutic and diagnostic relevance.

Validating RAC2 antibodies requires specificity testing via knockout controls or siRNA knockdown to ensure accurate detection. Their development has advanced research into immune cell signaling, offering insights into potential drug targets for modulating immune responses or treating RAC2-related pathologies.

       
关键字: RAC2抗体;RAC2;RAC2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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