The SASH1 (SAM and SH3 domain-containing protein 1) antibody is a crucial tool for studying the role of the SASH1 protein, encoded by the tumor suppressor gene *SASH1*. SASH1 is implicated in regulating cellular processes such as apoptosis, signal transduction, and cell adhesion. It is widely expressed in normal tissues, including the immune system, brain, and epithelial cells. Research highlights its downregulation in various cancers (e.g., breast, colorectal, and lung cancers), correlating with tumor progression, metastasis, and poor prognosis. SASH1’s tumor-suppressive functions involve inhibiting proliferation, migration, and invasion, often through pathways like PI3K/AKT and NF-κB.
The SASH1 antibody enables the detection and quantification of SASH1 protein levels in experimental models, facilitating investigations into its expression patterns, subcellular localization (primarily cytoplasmic), and interactions with signaling molecules. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Validating antibody specificity is critical, often achieved via knockout controls or siRNA knockdown. Clinically, SASH1 expression is being explored as a potential biomarker for cancer diagnosis or prognosis. Additionally, studies link SASH1 mutations to genetic disorders like dyschromatosis symmetrica hereditaria, underscoring its diverse biological roles beyond oncology. This antibody thus serves as a vital reagent in both cancer research and genetic disease studies.