SLC39A5抗体

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue lysate, Primary antibody: P05307(SLC39A5 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05307(SLC39A5 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The SLC39A5 antibody is a crucial tool for studying the solute carrier family 39 member 5 (SLC39A5), a zinc transporter protein encoded by the SLC39A5 gene. As part of the ZIP (Zrt-/Irt-like protein) family, SLC39A5 facilitates cellular zinc uptake, maintaining zinc homeostasis critical for enzymatic activity, immune regulation, and signal transduction. This transmembrane protein is expressed in tissues such as the intestines, liver, and pancreas, where zinc metabolism is vital. Dysregulation of SLC39A5 has been linked to metabolic disorders, cancers, and inflammatory diseases, making its detection pivotal for research.

SLC39A5 antibodies are typically developed using immunogenic peptides or recombinant protein fragments, validated via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help identify SLC39A5's expression patterns, subcellular localization (e.g., plasma membrane or vesicles), and its role in zinc-related pathologies. For instance, studies associate SLC39A5 overexpression with colorectal cancer progression and its polymorphisms with type 2 diabetes susceptibility.

High-quality SLC39A5 antibodies exhibit specificity confirmed by knockdown/knockout controls or competitive assays. Researchers rely on them to explore therapeutic targets, such as modulating zinc signaling in metabolic syndrome or tumor microenvironments. Commercial antibodies often include species reactivity data (human, mouse, rat) and application-specific optimizations. Understanding SLC39A5's function through these antibodies advances insights into zinc biology and its translational implications in disease mechanisms and treatment strategies.