**Background of GSR Antibody**
Glutathione reductase (GSR) is a critical enzyme in the cellular antioxidant defense system, responsible for maintaining reduced glutathione (GSH), a vital molecule that neutralizes reactive oxygen species (ROS) and mitigates oxidative stress. GSR catalyzes the reduction of oxidized glutathione (GSSG) to GSH using NADPH as a cofactor, ensuring the redox balance essential for cellular homeostasis. Dysregulation of GSR activity or expression is linked to various pathologies, including neurodegenerative disorders, cancer, and cardiovascular diseases, highlighting its role in oxidative stress-related mechanisms.
GSR antibodies are immunological tools designed to detect, quantify, and study the expression, localization, and function of GSR in biological samples. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to investigate GSR's involvement in disease pathways or therapeutic responses. For instance, reduced GSR levels have been observed in aging tissues and certain cancers, making it a potential biomarker or therapeutic target.
Commercially available GSR antibodies are often generated against specific epitopes of human or other species' GSR proteins, with validation for specificity and sensitivity across applications. Researchers utilize these antibodies to explore antioxidant defense mechanisms, evaluate drug efficacy in preclinical models, or diagnose oxidative stress-related conditions. As interest in redox biology grows, GSR antibodies remain indispensable for elucidating the enzyme's role in health and disease, bridging basic research and clinical applications.