HSPA1A抗体,Rabbit Polyclonal HSPA1A Antibody
  • HSPA1A抗体,Rabbit Polyclonal HSPA1A Antibody
  • HSPA1A抗体,Rabbit Polyclonal HSPA1A Antibody
  • HSPA1A抗体,Rabbit Polyclonal HSPA1A Antibody

HSPA1A抗体 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
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产品详情

中文名称:HSPA1A抗体英文名称:Rabbit Polyclonal HSPA1A Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3498 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: HSPA1A
2025-05-12 HSPA1A抗体 Rabbit Polyclonal HSPA1A Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3498 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesP36; ANX2; LIP2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV; HEL-S-270
WB Predicted band size39 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human ANXA2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: HepG2, NIH/3T3, K562, Hela and MCF7 cell, Primary antibody: P06981(ANXA2 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P06981(ANXA2 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是3篇关于HSPA1A抗体的代表性文献摘要(基于近年研究模拟):

1. **文献名称**:*HSPA1A as a biomarker for oxidative stress in neurodegenerative diseases*

**作者**:Chen et al. (2021)

**摘要**:验证了HSPA1A抗体(克隆号:3A3)在阿尔茨海默病模型中的特异性,通过siRNA敲低实验证明其能特异性识别脑组织中的HSPA1A蛋白,并发现其在神经元应激反应中的表达上调。

2. **文献名称**:*A novel monoclonal antibody distinguishes intracellular HSP70 isoforms in cancer*

**作者**:Rodriguez-Nuevo et al. (2019)

**摘要**:开发了一种新型单克隆抗体(EPR19802),通过质谱验证其对HSPA1A(而非HSPA8)的特异性,成功应用于流式细胞术和免疫荧光检测肿瘤细胞中HSPA1A的亚细胞定位。

3. **文献名称**:*Heat shock protein 70 antibodies in autoimmune disorders: Cross-reactivity analysis*

**作者**:Müller et al. (2020)

**摘要**:评估了市售HSPA1A抗体(如Abcam ab2787)在系统性红斑狼疮患者血清中的交叉反应性,发现部分抗体可能与非HSP蛋白发生非特异性结合,强调了抗体验证的重要性。

注:以上为模拟文献,实际引用需通过PubMed/Google Scholar检索关键词"HSPA1A antibody validation"、"HSP70 antibody specificity"获取真实文献。近期研究多聚焦于抗体在疾病诊断(如癌症、神经退行性疾病)及应激反应机制中的应用验证。

       

背景信息

The HSPA1A antibody targets the HSPA1A protein, a member of the heat shock protein 70 (HSP70) family, also known as HSP72 or HSP70-1. Encoded by the *HSPA1A* gene, this protein functions as a molecular chaperone, assisting in protein folding, preventing aggregation under stress, and facilitating the degradation of misfolded proteins. It is highly inducible in response to cellular stressors like heat shock, oxidative stress, or toxins, playing a critical role in maintaining proteostasis and cell survival.

HSPA1A antibodies are widely used in research to study the heat shock response, cellular stress pathways, and diseases linked to protein misfolding, such as cancer, neurodegenerative disorders (e.g., Alzheimer’s, Parkinson’s), and inflammatory conditions. These antibodies enable detection of HSPA1A expression via techniques like Western blotting, immunohistochemistry, ELISA, and flow cytometry. Specificity is crucial due to high homology among HSP70 family members; thus, antibodies are often validated against recombinant proteins or knockout cells.

In disease contexts, HSPA1A is implicated in both protective and pathological roles. For example, it supports cancer cell survival under hypoxia or chemotherapy, making it a potential therapeutic target. Conversely, its dysregulation may contribute to neurotoxicity in proteinopathies. Research using HSPA1A antibodies helps clarify its dual functions, guiding drug development and biomarker discovery. Commercial antibodies vary in host species, clonality, and conjugation, allowing flexibility in experimental design. Proper controls are essential to ensure accurate interpretation, given the protein’s stress-inducible nature and ubiquitous expression.

       
关键字: HSPA1A抗体;HSPA1A;HSPA1A Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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