**Background of ANGPT1 Antibody**
Angiopoietin-1 (ANGPT1) is a secreted glycoprotein belonging to the angiopoietin family, primarily known for its role in vascular development and stability. It binds to the Tie2 receptor tyrosine kinase on endothelial cells, promoting vessel maturation, reducing vascular permeability, and modulating inflammatory responses. ANGPT1 is critical in maintaining vascular quiescence and orchestrating interactions between endothelial cells and pericytes or smooth muscle cells.
ANGPT1 antibodies are essential tools for studying angiogenesis, vascular remodeling, and related pathologies, such as cancer, cardiovascular diseases, and inflammatory disorders. These antibodies enable the detection and quantification of ANGPT1 in various experimental setups, including Western blotting, immunohistochemistry (IHC), and enzyme-linked immunosorbent assays (ELISA). They also facilitate functional studies to explore ANGPT1's role in signaling pathways, tissue repair, and disease mechanisms.
Research using ANGPT1 antibodies has revealed its therapeutic potential, particularly in conditions involving vascular leakage or abnormal angiogenesis. For instance, recombinant ANGPT1 or agonist antibodies are investigated for treating sepsis or ischemic injuries, while inhibiting ANGPT1/Tie2 signaling is explored in anti-cancer strategies. Despite its protective roles, dysregulated ANGPT1 expression is linked to pathological angiogenesis, underscoring the need for precise targeting. Thus, ANGPT1 antibodies remain pivotal in both basic research and translational applications, bridging mechanistic insights with clinical innovation.