VIM抗体,Rabbit Polyclonal VIM Antibody
  • VIM抗体,Rabbit Polyclonal VIM Antibody
  • VIM抗体,Rabbit Polyclonal VIM Antibody
  • VIM抗体,Rabbit Polyclonal VIM Antibody

VIM抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:VIM抗体英文名称:Rabbit Polyclonal VIM Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3381 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: VIM
2025-05-12 VIM抗体 Rabbit Polyclonal VIM Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3381 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

WB Predicted band size54 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human VIM
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cell lysate, Primary antibody: P07112(VIM Antibody) at dilution 1/4000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 second    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P07112(VIM Antibody) at dilution 1/60. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07112(VIM Antibody) at dilution 1/60. (Original magnification: ×200)    


           

参考文献

以下是3篇与VIM(波形蛋白)抗体相关的经典研究文献示例,涵盖基础生物学及疾病机制方向:

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1. **文献名称**: *Vimentin: The Conundrum of the Intermediate Filament Gene Family*

**作者**: Franke, W.W., et al.

**摘要**: 该综述系统总结了波形蛋白(Vimentin)作为中间丝蛋白家族成员的结构特征、细胞功能及其在胚胎发育、细胞迁移中的作用,并讨论了其抗体在细胞分型研究中的应用价值。

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2. **文献名称**: *Vimentin in Cancer and Its Potential as a Molecular Target for Therapy*

**作者**: Satelli, A., & Li, S.

**摘要**: 研究揭示了肿瘤细胞中Vimentin表达与上皮-间质转化(EMT)及转移的关系,利用特异性抗体证实其作为转移性癌症的生物标志物,并探讨靶向Vimentin的治疗策略。

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3. **文献名称**: *Role of Vimentin in Immune Cell Recruitment and Lung Fibrosis*

**作者**: Mendez, M.G., et al.

**摘要**: 通过基因敲除和抗体阻断实验,发现Vimentin调控纤维化模型中免疫细胞浸润,提示其抗体可能用于抑制促纤维化信号通路,为抗纤维化药物开发提供依据。

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如需特定领域(如神经科学或自身免疫疾病)的文献,可进一步说明以调整检索方向。实际文献请通过PubMed或Google Scholar核实。

       

背景信息

Vimentin antibodies are immunological tools targeting vimentin, a type III intermediate filament protein expressed in mesenchymal cells. Vimentin plays crucial roles in maintaining cell integrity, organelle positioning, and cellular migration. It is dynamically involved in processes like mitosis, cell signaling, and stress responses. As a marker of epithelial-to-mesenchymal transition (EMT), vimentin overexpression is associated with cancer metastasis, fibrosis, and chronic inflammation, making it a research focus in oncology and immunopathology.

Vimentin antibodies are widely used in research to study cytoskeletal reorganization during EMT, tumor progression, and wound healing. In diagnostics, they help identify mesenchymal-derived cells in tissue samples, aiding cancer subtyping and stromal analysis. Notably, autoantibodies against vimentin have clinical significance in autoimmune diseases like rheumatoid arthritis and systemic lupus erythematosus, where they contribute to pathogenesis through molecular mimicry or post-translational modifications.

Commercial vimentin antibodies are validated for techniques including immunofluorescence, Western blotting, and flow cytometry. Challenges remain in specificity due to vimentin's structural homology with other intermediate filaments. Recent studies explore its extracellular roles in bacterial adhesion and viral entry, expanding potential therapeutic applications. Proper antibody validation remains critical, as non-specific binding can lead to misinterpretation in both research and clinical settings.

       
关键字: VIM抗体;VIM;VIM Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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