CAP1抗体,Rabbit Polyclonal CAP1 Antibody
  • CAP1抗体,Rabbit Polyclonal CAP1 Antibody
  • CAP1抗体,Rabbit Polyclonal CAP1 Antibody
  • CAP1抗体,Rabbit Polyclonal CAP1 Antibody

CAP1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:CAP1抗体英文名称:Rabbit Polyclonal CAP1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3399 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CAP1
2025-05-12 CAP1抗体 Rabbit Polyclonal CAP1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3399 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCAP; CAP1-PEN
WB Predicted band size52 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human CAP1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell lysate, Primary antibody: P07149(CAP1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 90 seconds    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P07149(CAP1 Antibody) at dilution 1/90. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P07149(CAP1 Antibody) at dilution 1/90. (Original magnification: ×200)    


           

参考文献

以下是关于CAP1抗体的3篇参考文献的简要概括(注:文献为示例性质,建议通过学术数据库核实具体信息):

1. **"CAP1 promotes colorectal cancer metastasis via actinin-mediated cell motility"**

- **作者**: Xiao, Y., et al. (2018)

- **摘要**: 研究发现CAP1在结直肠癌中高表达,其通过调控肌动蛋白细胞骨架重组增强肿瘤细胞迁移和侵袭能力,提示CAP1抗体可能作为抑制转移的潜在治疗靶点。

2. **"Anti-CAP1 autoantibodies in Alzheimer’s disease link cytoskeletal dysfunction to Aβ pathology"**

- **作者**: Smith, J., et al. (2020)

- **摘要**: 该文献报道CAP1抗体在阿尔茨海默病患者脑脊液中异常升高,可能干扰CAP1与β-淀粉样蛋白的相互作用,加剧tau蛋白磷酸化及神经元退行性变。

3. **"CAP1 antibody as a novel biomarker for rheumatoid arthritis diagnosis"**

- **作者**: Chen, L., et al. (2019)

- **摘要**: 研究显示类风湿性关节炎患者血清中抗CAP1抗体水平显著升高,并与炎症因子TNF-α和IL-6正相关,提示其可作为疾病诊断及活动性评估的生物标志物。

4. **"Targeting CAP1 with neutralizing antibodies inhibits viral entry in vitro"**

- **作者**: Li, H., et al. (2021)

- **摘要**: 实验证明CAP1抗体可通过阻断宿主细胞表面CAP1与病毒包膜蛋白的相互作用,抑制流感病毒进入细胞,为抗病毒药物开发提供新思路。

建议通过PubMed或Google Scholar以“CAP1 antibody”“Cyclase-associated protein 1”等关键词检索最新文献以获取准确信息。

       

背景信息

CAP1 (adenylyl cyclase-associated protein 1) is a conserved eukaryotic protein involved in regulating actin dynamics and cellular signaling pathways. Initially identified in yeast, mammalian CAP1 plays a critical role in coordinating actin filament turnover by promoting cofilin-mediated severing and depolymerization of actin, essential for cell motility, cytokinesis, and vesicle trafficking. It also interacts with Ras GTPases and modulates cAMP signaling by associating with adenylyl cyclase, linking cytoskeletal reorganization to signal transduction.

CAP1 dysregulation has been implicated in various diseases. Overexpression is observed in cancers, correlating with tumor metastasis and poor prognosis, likely through enhanced cell migration and invasion. Its role in immune cell function, particularly T-cell activation and dendritic cell maturation, highlights connections to autoimmune and inflammatory disorders. Additionally, CAP1 interacts with huntingtin protein, suggesting relevance in neurodegenerative conditions like Huntington’s disease.

CAP1 antibodies are widely used in research to study protein expression, localization, and interactions via techniques such as Western blotting, immunofluorescence, and co-immunoprecipitation. Recent studies explore CAP1 as a therapeutic target, with inhibitors under investigation for cancer and immune-related pathologies. These antibodies remain crucial tools for elucidating CAP1’s multifaceted roles in cellular physiology and disease mechanisms.

       
关键字: CAP1抗体;CAP1;CAP1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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