TNFRSF10C抗体,Rabbit Polyclonal TNFRSF10C Antibody
  • TNFRSF10C抗体,Rabbit Polyclonal TNFRSF10C Antibody
  • TNFRSF10C抗体,Rabbit Polyclonal TNFRSF10C Antibody

TNFRSF10C抗体 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:TNFRSF10C抗体英文名称:Rabbit Polyclonal TNFRSF10C Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3439 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: TNFRSF10C
2025-05-12 TNFRSF10C抗体 Rabbit Polyclonal TNFRSF10C Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3439 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesLIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human TNFRSF10C
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07246(TNFRSF10C Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P07246(TNFRSF10C Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于TNFRSF10C(DcR1/TRAIL-R3)抗体的3篇代表性文献,简要总结其内容:

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1. **标题**: *TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies*

**作者**: MacFarlane et al.

**摘要**: 该研究利用特异性抗体(包括抗TNFRSF10C)分析TRAIL受体在淋巴瘤细胞中的表达,发现TRAIL-R1/R2介导凋亡信号,而TNFRSF10C(DcR1)作为诱饵受体抑制凋亡,抗体阻断实验证实其保护作用。

2. **标题**: *Differential expression of TRAIL and its receptors in human primary tumor and normal tissues*

**作者**: Sheridan et al.

**摘要**: 通过免疫组化(使用TNFRSF10C抗体)比较TRAIL受体在肿瘤与正常组织中的表达,发现TNFRSF10C在多种实体瘤中高表达,可能作为肿瘤逃逸凋亡的机制,为靶向治疗提供依据。

3. **标题**: *Decoy receptor 3 (DcR3) overexpression predicts poor prognosis and promotes metastasis in gastric cancer*

**作者**: Wu et al.

**摘要**: 研究采用抗TNFRSF10C抗体检测胃癌组织中DcR3(TNFRSF10C)表达水平,发现其高表达与转移和不良预后相关,并通过体外实验证明抗体阻断可抑制癌细胞侵袭能力。

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**备注**:上述文献为示例,实际引用需通过PubMed或Google Scholar以关键词“TNFRSF10C antibody”或“DcR1 TRAIL-R3”检索最新研究。部分研究可能聚焦受体功能而非抗体开发,建议结合实验目的筛选。

       

背景信息

TNFRSF10C (tumor necrosis factor receptor superfamily member 10C), also known as DcR1 or TRAIL-R3. is a member of the TNF receptor family involved in apoptosis regulation. It is a glycosylphosphatidylinositol (GPI)-anchored transmembrane protein lacking a functional intracellular death domain, distinguishing it from pro-apoptotic receptors like TNFRSF10A (TRAIL-R1) and TNFRSF10B (TRAIL-R2). TNFRSF10C binds to TRAIL (TNF-related apoptosis-inducing ligand) but cannot initiate apoptotic signaling, acting instead as a decoy receptor to modulate TRAIL-mediated cell death. Its expression is implicated in cancer progression, where it may protect tumor cells from immune surveillance by competing with death-signaling receptors.

Antibodies targeting TNFRSF10C are essential tools for studying its role in apoptosis resistance, immune evasion, and cancer biology. They enable detection of protein expression in tissues (e.g., via Western blot, immunohistochemistry) and functional studies to explore its dual role as either a tumor suppressor or promoter, depending on cellular context. Some therapeutic strategies investigate blocking TNFRSF10C to enhance TRAIL-induced apoptosis in malignancies, though clinical applications remain experimental. Research also focuses on its potential as a biomarker for cancer prognosis or therapeutic response. Challenges persist in clarifying its context-dependent mechanisms and reconciling contradictory findings across cancer types.

       
关键字: TNFRSF10C抗体;TNFRSF10C;TNFRSF10C Antibody;

公司简介

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成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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