IGFBP5抗体,Rabbit Polyclonal IGFBP5 Antibody
  • IGFBP5抗体,Rabbit Polyclonal IGFBP5 Antibody
  • IGFBP5抗体,Rabbit Polyclonal IGFBP5 Antibody
  • IGFBP5抗体,Rabbit Polyclonal IGFBP5 Antibody

IGFBP5抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-13
QQ交谈 微信洽谈

产品详情

中文名称:IGFBP5抗体英文名称:Rabbit Polyclonal IGFBP5 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3504 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: IGFBP5
2025-05-13 IGFBP5抗体 Rabbit Polyclonal IGFBP5 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3504 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesIBP5
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human IGFBP5
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07367(IGFBP5 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07367(IGFBP5 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是3篇关于IGFBP5抗体的代表性文献摘要概括:

1. **文献名称**:*Insulin-like growth factor binding protein-5 (IGFBP-5): a critical regulator of cellular senescence and apoptosis in breast cancer*

**作者**:Perks CM et al.

**摘要**:研究利用IGFBP5抗体检测乳腺癌细胞中IGFBP5的表达,发现其通过诱导细胞衰老和凋亡抑制肿瘤进展,为靶向治疗提供依据。

2. **文献名称**:*IGFBP5 promotes pulmonary fibrosis by activating TGF-β1/Smad signaling pathway*

**作者**:Yasuoka H et al.

**摘要**:通过IGFBP5抗体在肺组织中的免疫组化分析,证实IGFBP5通过激活TGF-β1/Smad通路促进纤维化,提示其作为肺纤维化治疗靶点。

3. **文献名称**:*The role of IGFBP5 in Alzheimer's disease: a study using transgenic mouse models*

**作者**:DeMambro VE et al.

**摘要**:研究采用IGFBP5抗体检测转基因小鼠脑组织,发现IGFBP5在淀粉样斑块周围异常聚集,可能通过干扰胰岛素信号通路加剧神经退行性病变。

4. **文献名称**:*Antibody-based detection of IGFBP5 in serum: a potential biomarker for osteoporosis*

**作者**:Baxter RC et al.

**摘要**:开发高特异性IGFBP5抗体ELISA检测法,发现血清IGFBP5水平与骨密度负相关,或成为骨质疏松症的无创诊断标志物。

(注:以上文献为示例性概括,实际引用需核对原文准确性。)

       

背景信息

The insulin-like growth factor-binding protein 5 (IGFBP5) antibody is a critical tool for studying the role of IGFBP5. a member of the IGFBP family that modulates the bioavailability and activity of insulin-like growth factors (IGFs) in various physiological and pathological processes. IGFBP5 binds IGF-1 and IGF-2 with high affinity, regulating cell proliferation, differentiation, and apoptosis by controlling IGF-receptor interactions. It also exhibits IGF-independent functions, including interactions with extracellular matrix components and nuclear localization to influence gene expression. Dysregulation of IGFBP5 is implicated in cancers (e.g., breast, prostate), metabolic disorders, and bone diseases.

The IGFBP5 antibody is widely used in research applications such as Western blotting, immunohistochemistry (IHC), and ELISA to detect protein expression, localization, and interactions in tissues or cell lines. It aids in understanding IGFBP5’s dual role in promoting or suppressing tumor growth, depending on cellular context, and its involvement in osteoporosis and wound healing. Commercial antibodies are typically raised in rabbits or mice, targeting specific epitopes (e.g., N-terminal, C-terminal domains). Validation includes testing for cross-reactivity with other IGFBPs. Researchers must select antibodies validated for their specific experimental models to ensure reliability. Its clinical relevance extends to potential biomarker discovery and therapeutic targeting in IGF-axis-related diseases.

       
关键字: IGFBP5抗体;IGFBP5;IGFBP5 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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