MAGED1抗体,Rabbit Polyclonal MAGED1 Antibody
  • MAGED1抗体,Rabbit Polyclonal MAGED1 Antibody
  • MAGED1抗体,Rabbit Polyclonal MAGED1 Antibody
  • MAGED1抗体,Rabbit Polyclonal MAGED1 Antibody

MAGED1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-13
QQ交谈 微信洽谈

产品详情

中文名称:MAGED1抗体英文名称:Rabbit Polyclonal MAGED1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3540 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: MAGED1
2025-05-13 MAGED1抗体 Rabbit Polyclonal MAGED1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3540 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/1000-1/5000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesNRAGE, DLXIN-1
WB Predicted band size86 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human MAGED1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: P07433(MAGED1 Antibody) at dilution 1/1200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P07433(MAGED1 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07433(MAGED1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是3篇涉及MAGED1抗体的文献摘要信息,供参考:

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1. **文献名称**:*MAGED1 is a regulator of alternative splicing and DNA damage response in cancer cells*

**作者**:Lee, J. et al. (2020)

**摘要**:研究利用MAGED1特异性抗体,发现其在癌细胞中通过调控RNA剪接和DNA损伤修复通路影响化疗敏感性,敲除MAGED1可增强顺铂诱导的细胞凋亡。

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2. **文献名称**:*MAGE-D1 interacts with mitochondria and modulates reactive oxygen species production*

**作者**:Barker, P.A. et al. (2016)

**摘要**:通过免疫沉淀(使用MAGED1抗体)和细胞定位实验,证实MAGED1与线粒体蛋白相互作用,调控ROS水平,可能参与神经退行性疾病的发生机制。

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3. **文献名称**:*A novel monoclonal antibody against MAGED1 for immunohistochemical analysis of human tissues*

**作者**:Suzuki, T. et al. (2018)

**摘要**:开发了一种高特异性抗MAGED1单克隆抗体,验证其在多种癌症组织(如乳腺癌、黑色素瘤)中的表达差异,提示其作为潜在生物标志物的价值。

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注:以上文献信息为模拟示例,实际引用需通过PubMed/Google Scholar检索具体论文(关键词:MAGED1 antibody, cancer, biomarker)。

       

背景信息

MAGED1 (Melanoma-associated antigen D1) is a member of the MAGE protein family, which shares a conserved MAGE homology domain. Initially identified in cancer-testis antigens, MAGE proteins are normally expressed in germ cells but re-emerge in various cancers, making them potential immunotherapy targets. MAGED1. encoded on the X chromosome, stands out for its broader physiological roles beyond oncology. It interacts with signaling pathways like p53. Wnt/β-catenin, and receptor tyrosine kinases, influencing cell proliferation, apoptosis, and differentiation. Studies link MAGED1 to neurodevelopment, placental function, and circadian rhythm regulation. It binds RTL1/RTL1AS in placental trophoblasts, impacting fetal growth, and modulates dopamine receptor trafficking in neurons.

In disease contexts, MAGED1 dysregulation is implicated in neurodevelopmental disorders (e.g., Prader-Willi-like syndrome), intellectual disability, and cancers such as melanoma and neuroblastoma. MAGED1 antibodies are essential tools for detecting protein expression via Western blotting, immunohistochemistry, and immunofluorescence. They aid in studying its localization (nucleus/cytoplasm), interaction partners, and tissue-specific roles. Recent research explores MAGED1’s therapeutic potential, including its use in CAR-T or vaccine-based strategies. However, challenges remain in understanding its isoform-specific functions and regulatory mechanisms. MAGED1 knockout mice exhibit metabolic and behavioral abnormalities, underscoring its multifaceted biological significance.

       
关键字: MAGED1抗体;MAGED1;MAGED1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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