NTF4抗体,Rabbit Polyclonal NTF4 Antibody
  • NTF4抗体,Rabbit Polyclonal NTF4 Antibody
  • NTF4抗体,Rabbit Polyclonal NTF4 Antibody
  • NTF4抗体,Rabbit Polyclonal NTF4 Antibody

NTF4抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-13
QQ交谈 微信洽谈

产品详情

中文名称:NTF4抗体英文名称:Rabbit Polyclonal NTF4 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3571 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: NTF4
2025-05-13 NTF4抗体 Rabbit Polyclonal NTF4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3571 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/10-1/50 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesNT4, NT5, NT-4, NT-5, NTF5, GLC10, GLC1O, NT-4/5
WB Predicted band size22 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human NTF4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: 231 cells, Primary antibody: P07498(NTF4 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07498(NTF4 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P07498(NTF4 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于NTF4抗体的3篇示例文献概览(内容为虚构示例,仅供格式参考):

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1. **"Development and validation of a high-affinity monoclonal antibody against human Neurotrophin-4 (NTF4)"**

*Author: Lee, J. et al.*

摘要:本研究报道了一种新型NTF4单克隆抗体的开发,通过杂交瘤技术筛选出高特异性抗体,并通过ELISA、Western blot和免疫组化验证其在人脑组织中的结合能力。该抗体可用于神经退行性疾病中NTF4蛋白表达的定量检测。

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2. **"NTF4 antibody-based therapeutic targeting in Alzheimer's disease models"**

*Author: Rodriguez, S. et al.*

摘要:文章探讨了NTF4抗体在阿尔茨海默病小鼠模型中的治疗潜力。实验表明,抗体可通过血脑屏障中和异常聚集的NTF4蛋白,减少神经元凋亡并改善认知功能,提示其作为神经保护剂的潜在应用。

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3. **"Structural mapping of NTF4 epitopes using phage display technology"**

*Author: Gupta, R. & Wang, T.*

摘要:通过噬菌体展示技术解析NTF4抗体的抗原表位,发现抗体主要结合于NTF4蛋白的β-折叠区域。该研究为优化抗体亲和力及设计靶向药物提供了结构基础。

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注:以上文献为模拟示例,实际引用需通过PubMed或Web of Science等数据库检索真实研究。如需具体文献推荐,建议补充研究领域或应用场景(如疾病、实验方法等)。

       

背景信息

Neurotrophin-4 (NTF4), also known as NT-4 or NT-5 depending on species, is a member of the neurotrophin family of growth factors that play critical roles in neuronal survival, development, and plasticity. It binds to the tropomyosin receptor kinase B (TrkB) and the low-affinity p75 neurotrophin receptor, activating downstream signaling pathways involved in synaptic modulation, axon guidance, and cell differentiation. NTF4 is expressed in both the central and peripheral nervous systems and has been implicated in processes such as memory formation, pain regulation, and recovery from neural injury. Dysregulation of NTF4 signaling has been linked to neurodegenerative diseases (e.g., Alzheimer’s), mood disorders, and neuropathic pain.

Antibodies targeting NTF4 are essential tools for studying its expression, localization, and function in biological systems. They are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to quantify protein levels or visualize distribution in tissues. Commercial NTF4 antibodies are typically raised in hosts such as rabbits or mice using recombinant protein fragments or synthetic peptides. However, challenges remain in ensuring specificity due to high homology among neurotrophin family members. Recent research emphasizes the need for rigorous validation via knockout controls or neutralization assays. Such antibodies have advanced understanding of NTF4's role in neuroprotection and its potential as a therapeutic target, particularly in conditions involving neuronal degeneration or synaptic dysfunction.

       
关键字: NTF4抗体;NTF4;NTF4 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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