PRDX3抗体,Rabbit Polyclonal PRDX3 Antibody
  • PRDX3抗体,Rabbit Polyclonal PRDX3 Antibody
  • PRDX3抗体,Rabbit Polyclonal PRDX3 Antibody
  • PRDX3抗体,Rabbit Polyclonal PRDX3 Antibody

PRDX3抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-13
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产品详情

中文名称:PRDX3抗体英文名称:Rabbit Polyclonal PRDX3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3605 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PRDX3
2025-05-13 PRDX3抗体 Rabbit Polyclonal PRDX3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3605 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesAOP1, MER5, AOP-1, SP-22, HBC189, PRO1748, prx-III
WB Predicted band size28 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human PRDX3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Hela cells, 293T cells, MCF7 cells, human fetal brain tissue, Jurkat cells, Primary antibody: P07558(PRDX3 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P07558(PRDX3 Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07558(PRDX3 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于PRDX3抗体的3篇参考文献及其摘要概括:

1. **文献名称**:*Peroxiredoxin 3 Is a Redox-Dependent Target of Thiostrepton in Malignant Mesothelioma Cells*

**作者**:C. Riganti et al.

**摘要**:该研究揭示了PRDX3在恶性间皮瘤中的抗氧化作用,通过使用PRDX3抗体检测其表达水平,发现硫链丝霉素通过抑制PRDX3活性增强氧化应激,从而抑制肿瘤细胞生长。

2. **文献名称**:*PRDX3 Supports Mitochondrial Stress Adaptation in Neurodegeneration*

**作者**:A. M. Pickrell et al.

**摘要**:文章利用PRDX3抗体分析其在神经元线粒体中的定位,表明PRDX3通过清除活性氧保护神经元免受氧化损伤,并参与帕金森病等神经退行性疾病的病理调控。

3. **文献名称**:*PRDX3 as a Prognostic Biomarker in Gastric Cancer*

**作者**:Y. Li et al.

**摘要**:该研究通过免疫组化(使用PRDX3抗体)发现,PRDX3在胃癌组织中高表达且与患者不良预后相关,提示其可作为潜在治疗靶点和预后标志物。

(注:以上文献信息为示例,实际引用需以具体论文为准。)

       

背景信息

**Background of PRDX3 Antibody**

Peroxiredoxin-3 (PRDX3), a member of the peroxiredoxin family, is a mitochondrial antioxidant enzyme critical for neutralizing reactive oxygen species (ROS) and maintaining redox homeostasis. It plays a vital role in protecting mitochondrial components from oxidative damage, regulating apoptosis, and modulating cellular proliferation. PRDX3 is encoded by the *PRDX3* gene and is predominantly localized to the mitochondria, distinguishing it from other cytosolic peroxiredoxins.

PRDX3 antibodies are immunological tools designed to detect and quantify PRDX3 protein expression in research applications such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies are pivotal in studying PRDX3's involvement in oxidative stress-related pathologies, including neurodegenerative diseases, cancer, cardiovascular disorders, and diabetes. For instance, PRDX3 overexpression has been linked to cancer progression and chemoresistance, while its deficiency correlates with mitochondrial dysfunction and accelerated aging.

Structurally, PRDX3 functions as a homodimer, utilizing cysteine residues to catalyze peroxide reduction. Antibodies targeting PRDX3 often recognize specific epitopes, such as its C-terminal or catalytic domains, enabling researchers to assess its expression levels, subcellular localization, and post-translational modifications. Validation of PRDX3 antibodies is essential to ensure specificity, as cross-reactivity with other peroxiredoxin isoforms (e.g., PRDX1 or PRDX2) can compromise experimental accuracy.

Overall, PRDX3 antibodies are indispensable for exploring mitochondrial oxidative stress mechanisms, disease biomarkers, and therapeutic targets, bridging molecular insights with clinical applications.

       
关键字: PRDX3抗体;PRDX3;PRDX3 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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