PTPRE抗体

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P07574(PTPRE Antibody) at dilution 1/10. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P07574(PTPRE Antibody) at dilution 1/10. (Original magnification: ×200)    

  
  

The PTPRE antibody targets the protein tyrosine phosphatase receptor type E (PTPRE), a member of the protein tyrosine phosphatase (PTP) family. PTPRE, also known as PTPε, exists in two major isoforms: a transmembrane receptor-like form and a non-receptor intracellular variant. Structurally, it contains a catalytic domain responsible for dephosphorylating tyrosine residues on target proteins, regulating cellular signaling pathways. PTPRE plays a dual role in both promoting and inhibiting signal transduction, depending on cellular context. It is implicated in insulin signaling, immune response modulation, and neuronal development, interacting with kinases like Src-family kinases and growth factor receptors to maintain tyrosine phosphorylation balance.

Dysregulation of PTPRE is linked to diseases such as cancer, diabetes, and neurological disorders. Overexpression or mutations in PTPRE may contribute to tumor progression or metabolic dysfunction. The PTPRE antibody is a critical tool for studying its expression, localization, and function in tissues or cell lines. Researchers use it in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate PTPRE's role in signaling cascades or disease mechanisms. Its specificity and sensitivity enable insights into PTPRE's regulatory mechanisms, aiding drug discovery and therapeutic targeting of PTP-associated pathologies.