AOAH抗体,Rabbit Polyclonal AOAH Antibody
  • AOAH抗体,Rabbit Polyclonal AOAH Antibody
  • AOAH抗体,Rabbit Polyclonal AOAH Antibody
  • AOAH抗体,Rabbit Polyclonal AOAH Antibody

AOAH抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-14
QQ交谈 微信洽谈

产品详情

中文名称:AOAH抗体英文名称:Rabbit Polyclonal AOAH Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5044 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: AOAH
2025-05-14 AOAH抗体 Rabbit Polyclonal AOAH Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5044 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

WB Predicted band size65 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human AOAH
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HL-60 cell lysate, Primary antibody: P09775(AOAH Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09775(AOAH Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于AOAH(Acyloxyacyl Hydrolase)抗体的示例参考文献(模拟内容,建议通过学术数据库验证):

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1. **标题**:*AOAH-mediated LPS detoxification regulates systemic inflammation in mice*

**作者**:Smith, J.R. et al.

**摘要**:研究利用AOAH特异性抗体,证明AOAH通过水解内毒素(LPS)的脂质A部分减轻全身性炎症,缺失AOAH的小鼠表现出更强的炎症反应。

2. **标题**:*Antibody-based detection of AOAH expression in macrophage polarization*

**作者**:Li, X. & Zhang, H.

**摘要**:通过制备抗AOAH单克隆抗体,揭示巨噬细胞中AOAH的表达水平与M1/M2表型转换相关,提示其在免疫调控中的潜在作用。

3. **标题**:*AOAH deficiency exacerbates autoimmune arthritis via TLR4 signaling*

**作者**:Wang, Y. et al.

**摘要**:使用AOAH抗体检测发现,AOAH缺陷小鼠关节内LPS清除延迟,导致TLR4信号过度激活,加剧类风湿性关节炎模型症状。

4. **标题**:*Structural insights into AOAH enzyme activity through epitope mapping*

**作者**:Garcia, R. et al.

**摘要**:通过抗AOAH抗体的表位定位,揭示了AOAH催化结构域的关键区域,为开发调节其活性的治疗策略提供依据。

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建议通过PubMed或Google Scholar搜索关键词“AOAH antibody”、“Acyloxyacyl Hydrolase function”获取真实文献。

       

背景信息

AOAH (acyloxyacyl hydrolase) is an enzyme primarily produced by macrophages and neutrophils, playing a critical role in modulating innate immune responses. It specifically deacylates bacterial lipopolysaccharides (LPS), a key component of Gram-negative bacterial outer membranes. By cleaving secondary acyl chains from the lipid A moiety of LPS, AOAH converts highly inflammatory endotoxins into less stimulatory forms, thereby limiting excessive immune activation and preventing tissue damage during infections.

AOAH antibodies are tools used to study this enzyme’s expression, localization, and function. They enable researchers to detect AOAH in immune cells, assess its regulation under inflammatory conditions, and explore its role in sepsis, autoimmune diseases, or metabolic disorders. AOAH-deficient mice exhibit prolonged LPS-induced inflammation, highlighting its importance in immune homeostasis. Antibodies targeting AOAH also aid in investigating therapeutic strategies, such as enhancing endotoxin detoxification or modulating inflammatory pathways. Clinically, AOAH activity or its suppression has been linked to chronic inflammatory conditions, making related antibodies valuable for diagnostic or biomarker research. Their applications extend to understanding host-microbe interactions, as AOAH’s function influences both pathogen clearance and resolution of inflammation.

       
关键字: AOAH抗体;AOAH;AOAH Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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