SERPING1 抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human plasma tissue, Primary antibody: P12160(SERPING1  Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes    

  
  

The SERPING1 gene encodes C1 inhibitor (C1-INH), a serine protease inhibitor critical for regulating the complement system, intrinsic coagulation pathway, and contact system. Deficiencies in C1-INH, caused by SERPING1 mutations, are linked to hereditary angioedema (HAE), a disorder characterized by recurrent swelling attacks. Anti-SERPING1 antibodies are not typically associated with HAE but may arise in acquired angioedema (AAE), where autoantibodies bind to C1-INH, accelerating its degradation and causing functional deficiency. These autoantibodies are often secondary to lymphoproliferative disorders or autoimmune conditions.

In therapeutic contexts, monoclonal antibodies targeting components downstream of SERPING1 (e.g., bradykinin B2 receptor or plasma kallikrein) are used to treat HAE. For example, lanadelumab inhibits plasma kallikrein, preventing excessive bradykinin production. While not directly targeting SERPING1. these therapies address pathways dysregulated by C1-INH deficiency.

Research on SERPING1 antibodies also explores diagnostic applications, such as detecting autoantibodies in AAE or monitoring C1-INH levels. Understanding SERPING1-related mechanisms continues to inform novel biologics and precision medicine approaches for angioedema and complement-mediated disorders.