TOP2B抗体,Rabbit Polyclonal TOP2B Antibody
  • TOP2B抗体,Rabbit Polyclonal TOP2B Antibody
  • TOP2B抗体,Rabbit Polyclonal TOP2B Antibody
  • TOP2B抗体,Rabbit Polyclonal TOP2B Antibody

TOP2B抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-15
QQ交谈 微信洽谈

产品详情

中文名称:TOP2B抗体英文名称:Rabbit Polyclonal TOP2B Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6571 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: TOP2B
2025-05-15 TOP2B抗体 Rabbit Polyclonal TOP2B Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6571 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesFCGR1A; FCRI; CD64A; IGFR1
Entrez GeneID2209
clone5F5F8
WB Predicted band size42.6kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD64 (AA: extra 16-145) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of HL-60 cells using CD64 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using CD64 mouse mAb with DAB staining.    


           

参考文献

以下是3篇关于TOP2B(拓扑异构酶IIβ)抗体的虚构参考文献示例(注:文献为假设性描述,实际文献需通过学术数据库检索):

1. **文献名称**: "TOP2B as a therapeutic target in cancer: antibody-based inhibition strategies"

**作者**: Smith A, et al.

**摘要**: 研究报道了针对TOP2B的单克隆抗体在小鼠肿瘤模型中的抗增殖作用,表明通过抑制TOP2B活性可增强化疗药物敏感性,并减少耐药性。

2. **文献名称**: "Autoantibodies against TOP2B in neurodegenerative disorders"

**作者**: Chen L, et al.

**摘要**: 发现阿尔茨海默病患者血清中存在抗TOP2B自身抗体,可能与神经元DNA损伤和tau蛋白异常磷酸化相关,提示其在神经退行性疾病中的潜在生物标志物价值。

3. **文献名称**: "TOP2B antibody profiling in systemic lupus erythematosus"

**作者**: Gupta R, et al.

**摘要**: 系统性红斑狼疮(SLE)患者中抗TOP2B抗体的高表达与疾病活动度呈正相关,可能通过干扰DNA修复机制参与自身免疫反应。

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**注**:以上内容为示例性虚构,真实文献请通过PubMed、Web of Science或Google Scholar检索关键词如"TOP2B antibody"、"anti-TOP2B autoantibody"等获取。

       

背景信息

TOP2B (Topoisomerase II Beta) is a nuclear enzyme belonging to the type II topoisomerase family, which plays a critical role in DNA replication, transcription, and chromosome segregation by transiently breaking and rejoining double-stranded DNA to relieve torsional stress. Unlike its isoform TOP2A, which is predominantly expressed in proliferating cells and linked to cell cycle regulation, TOP2B is ubiquitously present in both dividing and non-dividing cells, particularly in neurons and post-mitotic tissues. This isoform is implicated in neurodevelopment, synaptic plasticity, and transcriptional regulation, with emerging roles in neurological disorders such as Alzheimer’s disease and ALS.

Antibodies targeting TOP2B are essential tools for studying its expression, localization, and function in diverse biological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate TOP2B's involvement in DNA repair mechanisms, chromatin remodeling, and responses to genotoxic stress. Additionally, TOP2B antibodies have clinical relevance in cancer research, as aberrant TOP2B expression or activity is associated with certain malignancies, including neuroblastoma and treatment-resistant tumors. Notably, TOP2B is a secondary target for some chemotherapeutic agents (e.g., etoposide), though its inhibition is often linked to off-target toxicity rather than therapeutic effects. Research utilizing these antibodies continues to clarify TOP2B's dual roles in maintaining genomic stability and contributing to disease pathogenesis, bridging molecular biology with therapeutic development.

       
关键字: TOP2B抗体;TOP2B;TOP2B Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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