TRIB1抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12330(TRIB1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The TRIB1 (Tribbles Pseudokinase 1) antibody is a crucial tool for studying the TRIB1 protein, a member of the Tribbles family of pseudokinases involved in regulating cellular processes such as proliferation, differentiation, and apoptosis. TRIB1 acts as a scaffold protein, modulating signaling pathways like MAPK/ERK and PI3K/AKT by interacting with kinases (e.g., MEK1) and transcription factors (e.g., C/EBPα). Its role in ubiquitin-mediated protein degradation, particularly through binding E3 ligases like COP1. links it to metabolic regulation, inflammation, and cancer. Dysregulation of TRIB1 is implicated in diseases such as acute myeloid leukemia, atherosclerosis, and lipid metabolism disorders.

TRIB1 antibodies enable detection and functional analysis in techniques including Western blotting, immunofluorescence, and immunohistochemistry. They are vital for exploring tissue-specific expression, protein-protein interactions, and post-translational modifications. Researchers also use these antibodies to study TRIB1's dual roles in oncogenesis—acting as tumor suppressor or promoter depending on cellular context. Validated antibodies with specificity confirmed via knockout controls are essential, given TRIB1's structural homology with other Tribbles family members (TRIB2. TRIB3). Overall, TRIB1 antibodies are pivotal for unraveling its complex regulatory networks and therapeutic potential in human diseases.