The SCGB1A1 antibody targets Secretoglobin Family 1A Member 1 (SCGB1A1), a small secreted protein also known as Clara cell secretory protein (CCSP) or uteroglobin-related protein 1 (UGRP1). SCGB1A1 is predominantly expressed in mucosal epithelial cells, particularly club cells in the respiratory tract and epithelial cells of the reproductive system. It belongs to the secretoglobin family, characterized by disulfide-linked homodimers or heterodimers that bind hydrophobic molecules, such as phospholipids or steroids, playing roles in immunomodulation, inflammation regulation, and cellular protection.
SCGB1A1 antibodies are widely used in research to identify and localize this protein in tissues, aiding studies on lung physiology, airway diseases (e.g., asthma, COPD), and reproductive biology. In diagnostics, SCGB1A1 serves as a biomarker for club cell dysfunction or injury, with decreased levels linked to lung damage. Additionally, its expression in certain cancers, including lung adenocarcinoma, has prompted investigations into its role in tumorigenesis. Commercial SCGB1A1 antibodies are typically monoclonal or polyclonal, validated for techniques like immunohistochemistry, immunofluorescence, and ELISA. Recent studies also explore its potential as a therapeutic target due to its anti-inflammatory properties. Understanding SCGB1A1 dynamics via antibody-based assays continues to advance insights into respiratory pathologies and epithelial cell biology.