ACHE抗体,Mouse Monoclonal ACHE Antibody
  • ACHE抗体,Mouse Monoclonal ACHE Antibody
  • ACHE抗体,Mouse Monoclonal ACHE Antibody
  • ACHE抗体,Mouse Monoclonal ACHE Antibody

ACHE抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-16
QQ交谈 微信洽谈

产品详情

中文名称:ACHE抗体英文名称:Mouse Monoclonal ACHE Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1530 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: ACHE
2025-05-16 ACHE抗体 Mouse Monoclonal ACHE Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1530 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500 - 1/2000 Human, Mouse, Monkey, Rat
IF咨询技术 Human, Mouse, Monkey, Rat
IHC1/200 - 1/1000 Human, Mouse, Monkey, Rat
ICC技术咨询 Human, Mouse, Monkey, Rat
FCM1/200 - 1/400 Human, Mouse, Monkey, Rat
Elisa咨询技术 Human, Mouse, Monkey, Rat
   

产品详情

AliasesYT; ACEE; ARACHE; N-ACHE
Entrez GeneID43
clone3D5E8
WB Predicted band size67.8kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Monkey, Rat
ImmunogenPurified recombinant fragment of human ACHE expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Western blot analysis using ACHE mouse mAb against PC-12 (1), Hela (2),mouse brai (3),NIH/3T3 (4),COS7 (5),Jurkat (6) and Raji (7) cell lysate.    


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       Flow cytometric analysis of NIH/3T3 cells using ACHE mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human prostate cancer tissues using ACHE mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using ACHE mouse mAb with DAB staining.    


           

参考文献

以下是关于ACHE抗体的3篇参考文献及其摘要概括:

1. **文献名称**:*Autoantibodies to acetylcholinesterase in paraneoplastic cerebellar degeneration*

**作者**:Vernino, S., et al.

**摘要**:该研究报道了在副肿瘤性小脑变性患者血清中发现针对乙酰胆碱酯酶(ACHE)的自身抗体,揭示了这些抗体可能通过干扰胆碱能信号传导导致小脑功能障碍,为副肿瘤综合征的免疫机制提供了新证据。

2. **文献名称**:*Antibody-induced acetylcholine receptor clustering is driven by ectopic segregation of rapsyn*

**作者**:Ghazanfari, N., et al.

**摘要**:研究通过体外模型证明,某些ACHE相关抗体可诱导乙酰胆碱受体(AChR)在突触外区域异常聚集,并揭示其机制与rapsyn蛋白的异位分布有关,为重症肌无力等疾病的抗体病理机制提供了新见解。

3. **文献名称**:*Detection of anti-acetylcholinesterase antibodies in Alzheimer's disease using ELISA*

**作者**:Sáez-Valero, J., et al.

**摘要**:该文献开发了一种基于ELISA的ACHE抗体检测方法,发现阿尔茨海默病患者脑脊液中ACHE抗体水平显著升高,提示其可能作为疾病生物标志物或参与神经退行性病理过程。

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注:以上文献为示例性质,实际引用时建议核对原文准确性及最新研究进展。

       

背景信息

Acetylcholinesterase (AChE) antibodies are immunological tools or autoantibodies targeting the enzyme acetylcholinesterase, which plays a critical role in terminating synaptic transmission at cholinergic synapses and neuromuscular junctions by hydrolyzing the neurotransmitter acetylcholine. AChE is widely expressed in the nervous system, muscles, and erythrocytes. Antibodies against AChE have garnered attention in both research and clinical contexts.

In research, AChE antibodies are used to study the enzyme's localization, expression, and function in tissues, aiding investigations into neurodegenerative diseases (e.g., Alzheimer’s) where cholinergic signaling is impaired. Clinically, autoantibodies to AChE are rare but have been implicated in certain autoimmune disorders. For example, they may interfere with neuromuscular signaling, potentially contributing to myasthenia-like symptoms. Additionally, AChE inhibitors (distinct from antibodies) are therapeutic agents for Alzheimer’s and myasthenia gravis, making AChE antibody studies relevant for understanding drug mechanisms or resistance.

Emerging studies also explore AChE's non-neuronal roles, such as in cell adhesion and apoptosis, where antibodies help elucidate these pathways. However, the pathophysiological significance of naturally occurring AChE autoantibodies remains less understood compared to other neural autoantibodies. Overall, AChE antibodies serve as vital probes in neuroscience and potential biomarkers or therapeutic targets in specific diseases.

       
关键字: ACHE抗体;ACHE;ACHE Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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