SLC2A4抗体,Mouse Monoclonal SLC2A4 Antibody
  • SLC2A4抗体,Mouse Monoclonal SLC2A4 Antibody
  • SLC2A4抗体,Mouse Monoclonal SLC2A4 Antibody
  • SLC2A4抗体,Mouse Monoclonal SLC2A4 Antibody

SLC2A4抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-16
QQ交谈 微信洽谈

产品详情

中文名称:SLC2A4抗体英文名称:Mouse Monoclonal SLC2A4 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1566 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: SLC2A4
2025-05-16 SLC2A4抗体 Mouse Monoclonal SLC2A4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1566 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesGLUT4
Entrez GeneID6517
clone3G10A3
WB Predicted band size54.8kDa
Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenPurified recombinant fragment of human SLC2A4 (AA: 224-353 ) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using SLC2A4 mouse mAb against HeLa (1), NIH3T3 (2), 3T3-L1 (3) cell lysate and Mouse heart (4) tissue lysate.    


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       Immunofluorescence analysis of HeLa cells using SLC2A4 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Immunofluorescence analysis of HepG2 cells using SLC2A4 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Flow cytometric analysis of HeLa cells using SLC2A4 mouse mAb (green) and negative control (purple).    


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       Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using SLC2A4 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human cardiac muscle tissues using SLC2A4 mouse mAb with DAB staining.    


           

参考文献

以下是关于SLC2A4抗体的3篇参考文献及其摘要概括:

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1. **文献名称**:*Insulin resistance is associated with reduced plasma membrane GLUT4 content in skeletal muscle of patients with type 2 diabetes*

**作者**:Garvey WT, Maianu L, Hancock JA, Golichowski AM

**摘要**:该研究使用SLC2A4抗体(针对GLUT4蛋白)通过Western blot和免疫荧光技术,发现2型糖尿病患者骨骼肌中质膜GLUT4含量显著降低,提示胰岛素抵抗与GLUT4转运障碍相关。

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2. **文献名称**:*Exercise training increases GLUT4 protein expression in obese Zucker rats*

**作者**:Ren JM, Semenkovich CF, Gulve EA, Holloszy JO

**摘要**:通过SLC2A4抗体检测肥胖大鼠骨骼肌和脂肪组织中GLUT4表达水平,发现运动训练可显著上调GLUT4蛋白表达,改善胰岛素敏感性,为运动干预代谢疾病提供依据。

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3. **文献名称**:*Adipose tissue-specific deletion of GLUT4 alters insulin resistance and lipid metabolism*

**作者**:Abel ED, Peroni OD, Kim JK, Kim YB, Boss O, Hadro E

**摘要**:研究利用SLC2A4抗体进行基因敲除小鼠模型的蛋白分析,揭示脂肪组织GLUT4缺失导致全身胰岛素抵抗和血脂异常,强调脂肪细胞GLUT4在代谢调控中的关键作用。

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这些文献均通过SLC2A4抗体探究GLUT4蛋白在胰岛素信号通路、运动干预及代谢疾病中的分子机制,涵盖糖尿病、肥胖等研究领域。

       

背景信息

The SLC2A4 antibody targets the solute carrier family 2 member 4 (SLC2A4), also known as glucose transporter type 4 (GLUT4), a critical insulin-regulated transporter responsible for facilitating glucose uptake into adipose and muscle tissues. GLUT4 is stored in intracellular vesicles under basal conditions and translocates to the cell membrane upon insulin stimulation, a process central to maintaining glucose homeostasis. Dysregulation of GLUT4 expression or trafficking is closely associated with insulin resistance, type 2 diabetes, and metabolic syndrome.

SLC2A4 antibodies are widely used in research to detect GLUT4 protein levels, localization, and dynamics in tissues or cell models. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to study GLUT4 membrane translocation, expression changes in metabolic disorders, or responses to therapeutic interventions. These antibodies are often raised in hosts like rabbits or mice, targeting specific epitopes within GLUT4’s cytoplasmic, extracellular, or C-terminal domains.

Validation of SLC2A4 antibodies is essential, as variations in isoform specificity, cross-reactivity, or sensitivity can affect experimental outcomes. Knockout controls or siRNA-mediated silencing are recommended to confirm antibody specificity. Research utilizing SLC2A4 antibodies has advanced understanding of insulin signaling pathways, adipose-muscle crosstalk in metabolism, and potential drug targets for diabetes. However, challenges remain in standardizing GLUT4 quantification due to its low basal membrane presence and tissue-specific expression patterns.

       
关键字: SLC2A4抗体;SLC2A4;SLC2A4 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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