UMPS抗体,Rabbit Polyclonal UMPS Antibody
  • UMPS抗体,Rabbit Polyclonal UMPS Antibody
  • UMPS抗体,Rabbit Polyclonal UMPS Antibody
  • UMPS抗体,Rabbit Polyclonal UMPS Antibody

UMPS抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-16
QQ交谈 微信洽谈

产品详情

中文名称:UMPS抗体英文名称:Rabbit Polyclonal UMPS Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2211 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: UMPS
2025-05-16 UMPS抗体 Rabbit Polyclonal UMPS Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2211 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesOPRT
WB Predicted band size52 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human UMPS
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue lysate, Primary antibody: P02353(UMPS Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P02353(UMPS Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于UMPS抗体的3篇参考文献示例(内容为模拟概括,建议根据实际文献调整):

---

1. **文献名称**:*Development of a Monoclonal Antibody Against Human UMPS for Immunohistochemical Analysis*

**作者**:Smith A, et al.

**摘要**:本研究报道了一种新型抗人UMPS单克隆抗体的开发,验证了其在Western blot和免疫组化中的特异性,并应用于检测多种癌症组织中UMPS蛋白的表达水平,发现其与5-氟尿嘧啶化疗敏感性相关。

2. **文献名称**:*UMPS Deficiency in Hereditary Orotic Aciduria: Immunoblotting and Genetic Correlation*

**作者**:Johnson RL, et al.

**摘要**:通过使用UMPS抗体进行免疫印迹分析,研究者发现乳清酸尿症患者细胞中UMPS蛋白表达缺失,并进一步鉴定出UMPS基因的复合杂合突变,为疾病诊断提供了蛋白水平的证据。

3. **文献名称**:*Quantitative UMPS Expression Profiling in Colorectal Cancer Using Antibody-Based Techniques*

**作者**:Lee H, et al.

**摘要**:该研究利用UMPS抗体对结直肠癌组织进行定量分析,发现高表达UMPS的肿瘤对5-FU化疗响应率显著降低,提示UMPS可能作为化疗耐药性的预测标志物。

---

注:以上文献为示例性质,具体文献需通过PubMed或Web of Science等平台以关键词“UMPS antibody”、“UMPS immunohistochemistry”或“UMPS deficiency”检索获取。

       

背景信息

UMPS (Uridine Monophosphate Synthase) is a bifunctional enzyme critical in the *de novo* pyrimidine biosynthesis pathway, catalyzing two sequential reactions: the conversion of orotate to orotidine monophosphate (OMP) via its orotate phosphoribosyltransferase (OPRT) domain, followed by the decarboxylation of OMP to uridine monophosphate (UMP) through its orotidine 5'-phosphate decarboxylase (OMPDC) domain. UMP serves as a precursor for all pyrimidine nucleotides (UTP, CTP), essential for DNA/RNA synthesis and cellular metabolism. Dysregulation of UMPS activity is linked to metabolic disorders, such as hereditary orotic aciduria (a rare autosomal recessive disease), and cancer progression due to increased nucleotide demand in proliferating cells.

UMPS antibodies are valuable tools in biomedical research, enabling the detection and quantification of UMPS expression in tissues or cell lines. They are used to investigate pyrimidine metabolism abnormalities, evaluate chemotherapeutic responses (e.g., 5-fluorouracil, which targets thymidylate synthase downstream of UMPS), and explore UMPS as a potential biomarker in cancers like hepatocellular carcinoma. These antibodies support techniques like Western blotting, immunohistochemistry, and ELISA, aiding in both diagnostic and mechanistic studies. Recent studies also highlight UMPS's role in drug resistance, making its antibodies relevant for developing targeted therapies.

       
关键字: UMPS抗体;UMPS;UMPS Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

UMPS抗体—艾普蒂相关厂家报价

产品名称 价格   公司名称 报价日期
¥1950
VIP3年
上海沪震实业有限公司
2025-07-30
¥960.00
VIP10年
北京索莱宝科技有限公司
2025-07-30
询价
VIP3年
维百奥(北京)生物科技有限公司
2025-07-30
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.