SLC3A2抗体,Rabbit Polyclonal SLC3A2 Antibody
  • SLC3A2抗体,Rabbit Polyclonal SLC3A2 Antibody
  • SLC3A2抗体,Rabbit Polyclonal SLC3A2 Antibody
  • SLC3A2抗体,Rabbit Polyclonal SLC3A2 Antibody

SLC3A2抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-16
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产品详情

中文名称:SLC3A2抗体英文名称:Rabbit Polyclonal SLC3A2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2243 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: SLC3A2
2025-05-16 SLC3A2抗体 Rabbit Polyclonal SLC3A2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2243 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

Aliases4F2; CD98; MDU1; 4F2HC; 4T2HC; NACAE; CD98HC
WB Predicted band size68 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human SLC3A2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A375 and Jurkat cell lysates, Primary antibody: P02481(SLC3A2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P02481(SLC3A2 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P02481(SLC3A2 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于SLC3A2抗体的3篇示例文献(内容为虚构示例,仅作格式参考):

1. **文献名称**: "SLC3A2/CD98hc as a Biomarker in Tumor Angiogenesis and Metastasis"

**作者**: Prasad, R. et al.

**摘要**: 研究通过免疫组化及Western blot分析,发现SLC3A2在多种实体瘤中高表达,其抗体阻断实验表明SLC3A2通过调控整合素信号通路促进肿瘤血管生成和转移,提示其作为治疗靶点的潜力。

2. **文献名称**: "Structural Insights into SLC3A2-CD98 Complex and Antibody Recognition"

**作者**: Yan, L. et al.

**摘要**: 通过冷冻电镜解析SLC3A2与CD98轻链的复合物结构,揭示其介导氨基酸转运的分子机制。研究利用特异性抗体验证关键表位,为开发靶向SLC3A2的抗体药物提供结构基础。

3. **文献名称**: "SLC3A2 Antibody Blocks Viral Entry by Disrupting Integrin β1 Interaction"

**作者**: Coyne, C.B. et al.

**摘要**: 发现SLC3A2作为某些肠道病毒的宿主受体,其抗体可竞争性抑制病毒与细胞表面整合素β1的结合,阻断病毒内化,为抗病毒治疗提供新策略。

4. **文献名称**: "Targeting SLC3A2 in Immune Checkpoint Therapy-Resistant Cancers"

**作者**: Kim, S. et al.

**摘要**: 研究显示,SLC3A2抗体联合PD-1抑制剂可增强T细胞对耐药肿瘤的杀伤作用,机制涉及SLC3A2对肿瘤微环境中T细胞代谢的重编程作用。

(注:以上文献信息为模拟生成,实际引用需查询真实数据库如PubMed或Google Scholar。)

       

背景信息

The SLC3A2 antibody targets the solute carrier family 3 member 2 (SLC3A2), a transmembrane glycoprotein also known as CD98 or 4F2. SLC3A2 is a key component of heterodimeric amino acid transporters, forming complexes with light chains like SLC7A5 (LAT1) or SLC7A8 (LAT2) to mediate cellular uptake of neutral and cationic amino acids. These transporters play critical roles in nutrient sensing, cell growth, and immune regulation. SLC3A2 is ubiquitously expressed, particularly in proliferating cells, and is overexpressed in various cancers, where it supports tumor metabolism and metastasis.

SLC3A2 antibodies are widely used in research to study protein expression, localization, and function in normal and pathological contexts. They enable detection via techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry. Research highlights its involvement in mTOR signaling, T-cell activation, and tumor microenvironment adaptation. Dysregulation of SLC3A2 is linked to cancer progression, autoimmune disorders, and metabolic diseases, making it a potential therapeutic target.

Antibodies against SLC3A2 also aid in exploring its role in cell adhesion, as the protein interacts with integrins to regulate intracellular signaling pathways. Studies using these antibodies have advanced understanding of its dual roles in amino acid transport and integrin-mediated signaling, emphasizing its importance in cellular physiology and disease mechanisms.

       
关键字: SLC3A2抗体;SLC3A2;SLC3A2 Antibody;

公司简介

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