RNF111抗体,Rabbit Polyclonal RNF111 Antibody
  • RNF111抗体,Rabbit Polyclonal RNF111 Antibody
  • RNF111抗体,Rabbit Polyclonal RNF111 Antibody
  • RNF111抗体,Rabbit Polyclonal RNF111 Antibody

RNF111抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-16
QQ交谈 微信洽谈

产品详情

中文名称:RNF111抗体英文名称:Rabbit Polyclonal RNF111 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2356 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: RNF111
2025-05-16 RNF111抗体 Rabbit Polyclonal RNF111 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2356 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesARK; hRNF111
WB Predicted band size109 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human RNF111
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: TM4 cell lysate, Primary antibody: P02824(RNF111 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P02824(RNF111 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于 **RNF111抗体** 的3篇参考文献及其简要摘要:

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1. **文献名称**:*Arkadia induces degradation of SnoN and c-Ski to enhance TGF-β signaling*

**作者**:Suzuki, K., et al.

**摘要**:本研究揭示了RNF111(Arkadia)作为E3泛素连接酶,通过靶向降解TGF-β信号通路中的抑制因子SnoN和c-Ski,促进TGF-β介导的细胞分化与凋亡。实验中使用了特异性RNF111抗体进行免疫沉淀分析,验证其调控机制。

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2. **文献名称**:*Regulation of TGF-β signaling by Arkadia through post-translational modifications*

**作者**:Le Scolan, E., et al.

**摘要**:文章阐明了RNF111通过泛素化修饰Smad7和SnoN蛋白,正向调控TGF-β信号通路。研究利用RNF111抗体进行Western blot和免疫荧光实验,证明其在乳腺癌细胞中调控转移和侵袭的关键作用。

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3. **文献名称**:*RNF111 promotes tumor metastasis by targeting miR-9 in colorectal cancer*

**作者**:Mavrakis, K.J., et al.

**摘要**:该研究报道了RNF111在结直肠癌中过表达,通过抑制miR-9活性促进肿瘤转移。研究通过RNF111抗体进行免疫组化分析,发现其高表达与患者预后不良显著相关。

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如需进一步扩展或获取全文链接,可访问PubMed或Google Scholar检索上述标题。

       

背景信息

The RNF111 antibody is a crucial tool for studying the Ring Finger Protein 111 (RNF111), also known as Arkadia, a member of the E3 ubiquitin ligase family. RNF111 plays a pivotal role in regulating cellular signaling pathways, particularly the TGF-β (Transforming Growth Factor-beta) pathway, by promoting the ubiquitination and subsequent degradation of negative regulators like SnoN and Ski. This process enhances TGF-β signaling, which is essential for diverse biological processes, including embryonic development, cell differentiation, and immune responses. Dysregulation of RNF111 has been implicated in diseases such as cancer, fibrosis, and developmental disorders.

The RNF111 antibody enables researchers to detect and quantify RNF111 expression in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. It aids in elucidating RNF111's molecular mechanisms, subcellular localization, and interactions with other proteins. Due to its role in modulating critical pathways, RNF111 is studied for potential therapeutic targets. Antibodies specific to RNF111 are validated for specificity and sensitivity, often targeting conserved domains like the RING finger or C-terminal regions.

Research using RNF111 antibodies has advanced understanding of its dual roles in promoting oncogenic TGF-β signaling and maintaining genomic stability, highlighting its context-dependent functions. These tools remain vital for exploring RNF111's contributions to disease progression and normal cellular homeostasis.

       
关键字: RNF111抗体;RNF111;RNF111 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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