The GFRA4 (GDNF family receptor alpha 4) antibody is a tool used to detect and study the GFRA4 protein, a member of the GDNF receptor family. GFRA4 is a glycosylphosphatidylinositol (GPI)-anchored cell surface receptor that primarily binds persephin (PSPN), a neurotrophic factor involved in neuronal survival and differentiation. Unlike other GDNF family receptors (GFRα1-3), GFRA4 shows distinct tissue expression, notably in peripheral tissues like the thyroid, kidney, and adrenal glands, as well as in specific neuronal populations. It functions as a co-receptor with RET tyrosine kinase to activate downstream signaling pathways, including MAPK and PI3K-AKT, which regulate cell proliferation, differentiation, and apoptosis. Research on GFRA4 has linked it to neurodevelopmental processes, neuroendocrine regulation, and diseases such as neuroblastoma and Hirschsprung's disease. The GFRA4 antibody is essential for immunohistochemistry, Western blotting, and flow cytometry, enabling researchers to map protein expression, investigate signaling mechanisms, and explore therapeutic targets in neurological disorders and cancers. Its specificity and reliability make it a critical reagent in both basic and translational studies.